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Neuron-to-neuron α-synuclein propagation in vivo is independent of neuronal injury

Overview of attention for article published in Acta Neuropathologica Communications, March 2015
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (83rd percentile)
  • Average Attention Score compared to outputs of the same age and source

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1 news outlet
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1 X user

Citations

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105 Mendeley
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Title
Neuron-to-neuron α-synuclein propagation in vivo is independent of neuronal injury
Published in
Acta Neuropathologica Communications, March 2015
DOI 10.1186/s40478-015-0198-y
Pubmed ID
Authors

Ayse Ulusoy, Ruth E Musgrove, Raffaella Rusconi, Michael Klinkenberg, Michael Helwig, Anja Schneider, Donato A Di Monte

Abstract

Interneuronal propagation of α-synuclein has been demonstrated in a variety of experimental models and may be involved in disease progression during the course of human synucleinopathies. The aim of this study was to assess the role that neuronal injury or, vice versa, cell integrity could have in facilitating interneuronal α-synuclein transfer and consequent protein spreading in an in vivo animal model. Viral vectors carrying the DNA for human α-synuclein were injected into the rat vagus nerve to trigger protein overexpression in the medulla oblongata and consequent spreading of human α-synuclein toward pons, midbrain and forebrain. Two vector preparations sharing the same viral construct were manufactured using identical procedures with the exception of methods for their purification. They were also injected at concentrations that induced comparable levels of α-synuclein transduction/overexpression in the medulla oblongata. α-Synuclein load was associated with damage (at 6 weeks post injection) and death (at 12 weeks) of medullary neurons after treatment with only one of the two vector preparations. Of note, neuronal injury and degeneration was accompanied by a substantial reduction of caudo-rostral propagation of human α-synuclein. Interneuronal α-synuclein transfer, which underlies protein spreading from the medulla oblongata to more rostral brain regions in this rat model, is not a mere consequence of passive release from damaged or dead neurons. Neuronal injury and degeneration did not exacerbate α-synuclein propagation. In fact, data suggest that cell-to-cell passage of α-synuclein may be particularly efficient between intact, relatively healthy neurons.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 105 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 <1%
Germany 1 <1%
Unknown 103 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 25 24%
Researcher 23 22%
Student > Bachelor 11 10%
Student > Master 10 10%
Student > Doctoral Student 7 7%
Other 12 11%
Unknown 17 16%
Readers by discipline Count As %
Neuroscience 29 28%
Agricultural and Biological Sciences 21 20%
Biochemistry, Genetics and Molecular Biology 15 14%
Medicine and Dentistry 10 10%
Pharmacology, Toxicology and Pharmaceutical Science 3 3%
Other 6 6%
Unknown 21 20%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 April 2015.
All research outputs
#3,195,800
of 22,805,349 outputs
Outputs from Acta Neuropathologica Communications
#700
of 1,372 outputs
Outputs of similar age
#43,404
of 263,322 outputs
Outputs of similar age from Acta Neuropathologica Communications
#7
of 13 outputs
Altmetric has tracked 22,805,349 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,372 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.9. This one is in the 46th percentile – i.e., 46% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,322 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.