↓ Skip to main content

Interaction of prion protein with acetylcholinesterase: potential pathobiological implications in prion diseases

Overview of attention for article published in Acta Neuropathologica Communications, April 2015
Altmetric Badge

About this Attention Score

  • Average Attention Score compared to outputs of the same age
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

twitter
3 X users

Citations

dimensions_citation
12 Dimensions

Readers on

mendeley
30 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Interaction of prion protein with acetylcholinesterase: potential pathobiological implications in prion diseases
Published in
Acta Neuropathologica Communications, April 2015
DOI 10.1186/s40478-015-0188-0
Pubmed ID
Authors

Joan Torrent, Alba Vilchez-Acosta, Diego Muñoz-Torrero, Marie Trovaslet, Florian Nachon, Arnaud Chatonnet, Katarina Grznarova, Isabelle Acquatella-Tran Van Ba, Ronan Le Goffic, Laetitia Herzog, Vincent Béringue, Human Rezaei

Abstract

The prion protein (PrP) binds to various molecular partners, but little is known about their potential impact on the pathogenesis of prion diseases Here, we show that PrP can interact in vitro with acetylcholinesterase (AChE), a key protein of the cholinergic system in neural and non-neural tissues. This heterologous association induced aggregation of monomeric PrP and modified the structural properties of PrP amyloid fibrils. Following its recruitment into PrP fibrils, AChE loses its enzymatic activity and enhances PrP-mediated cytotoxicity. Using several truncated PrP variants and specific tight-binding AChE inhibitors (AChEis), we then demonstrate that the PrP-AChE interaction requires two mutually exclusive sub-sites in PrP N-terminal domain and an aromatic-rich region at the entrance of AChE active center gorge. We show that AChEis that target this site impair PrP-AChE complex formation and also limit the accumulation of pathological prion protein (PrPSc) in prion-infected cell cultures. Furthermore, reduction of AChE levels in prion-infected heterozygous AChE knock-out mice leads to slightly but significantly prolonged incubation time. Finally, we found that AChE levels were altered in prion-infected cells and tissues, suggesting that AChE might be directly associated with abnormal PrP. Our results indicate that AChE deserves consideration as a new actor in expanding pathologically relevant PrP morphotypes and as a therapeutic target.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
South Africa 1 3%
Unknown 29 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 5 17%
Professor 4 13%
Student > Bachelor 4 13%
Student > Ph. D. Student 4 13%
Student > Doctoral Student 3 10%
Other 8 27%
Unknown 2 7%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 9 30%
Agricultural and Biological Sciences 7 23%
Chemistry 3 10%
Immunology and Microbiology 2 7%
Neuroscience 2 7%
Other 4 13%
Unknown 3 10%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 January 2021.
All research outputs
#14,713,620
of 24,677,985 outputs
Outputs from Acta Neuropathologica Communications
#1,120
of 1,517 outputs
Outputs of similar age
#133,823
of 269,153 outputs
Outputs of similar age from Acta Neuropathologica Communications
#11
of 15 outputs
Altmetric has tracked 24,677,985 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,517 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 13.3. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 269,153 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.