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Plasmodium falciparum susceptibility to standard and potential anti-malarial drugs in Dakar, Senegal, during the 2013–2014 malaria season

Overview of attention for article published in Malaria Journal, February 2015
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  • Good Attention Score compared to outputs of the same age (66th percentile)

Mentioned by

twitter
1 tweeter
patent
1 patent

Citations

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25 Dimensions

Readers on

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57 Mendeley
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Title
Plasmodium falciparum susceptibility to standard and potential anti-malarial drugs in Dakar, Senegal, during the 2013–2014 malaria season
Published in
Malaria Journal, February 2015
DOI 10.1186/s12936-015-0589-3
Pubmed ID
Authors

Bécaye Fall, Cheikhou Camara, Mansour Fall, Aminata Nakoulima, Pierre Dionne, Bakary Diatta, Yaya Diemé, Boubacar Wade, Bruno Pradines

Abstract

In 2006, the Senegalese National Malaria Control Programme recommended artemisinin-based combination therapy (ACT) as the first-line treatment for uncomplicated malaria. Since the introduction of ACT, there have been very few reports on the level of Plasmodium falciparum resistance to anti-malarial drugs. An ex vivo susceptibility study was conducted on local isolates obtained from the Hôpital Principal de Dakar (Dakar, Senegal) from November 2013 to January 2014. Eighteen P. falciparum isolates were sussessfully assessed for ex vivo susceptibility to chloroquine (CQ), quinine (QN), monodesethylamodiaquine (MDAQ), the active metabolite of amodiaquine, mefloquine (MQ), lumefantrine (LMF), artesunate (AS), dihydroartemisinin (DHA), the active metabolite of artemisinin derivatives, pyronaridine (PND), piperaquine (PPQ), and, Proveblue (PVB), a methylene blue preparation, using the HRP2-based ELISA test. The prevalence of isolates with reduced susceptibility was 55.6% for MQ, 50% for CQ, 5.6% for QN and MDAQ, and 0% for DHA, AS and LMF. The mean IC50 for PND, PPQ and PVB were 5.8 nM, 32.2 nM and 5.3 nM, respectively. The prevalence of isolates with a reduced susceptibility to MQ remains high and stable in Dakar. Since 2004, the prevalence of CQ resistance decreased, but rebounded in 2013 in Dakar. PND, PPQ and PVB showed high in vitro activity in P. falciparum parasites from Dakar.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Burkina Faso 1 2%
United States 1 2%
Unknown 54 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 18%
Student > Master 8 14%
Researcher 7 12%
Student > Doctoral Student 6 11%
Student > Postgraduate 6 11%
Other 13 23%
Unknown 7 12%
Readers by discipline Count As %
Medicine and Dentistry 16 28%
Agricultural and Biological Sciences 11 19%
Biochemistry, Genetics and Molecular Biology 8 14%
Pharmacology, Toxicology and Pharmaceutical Science 5 9%
Immunology and Microbiology 2 4%
Other 8 14%
Unknown 7 12%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 November 2021.
All research outputs
#6,616,882
of 21,108,726 outputs
Outputs from Malaria Journal
#2,157
of 5,297 outputs
Outputs of similar age
#80,253
of 248,372 outputs
Outputs of similar age from Malaria Journal
#1
of 1 outputs
Altmetric has tracked 21,108,726 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 5,297 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 248,372 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them