Title |
Diverse functions of miR-373 in cancer
|
---|---|
Published in |
Journal of Translational Medicine, May 2015
|
DOI | 10.1186/s12967-015-0523-z |
Pubmed ID | |
Authors |
Furong Wei, Chuanhua Cao, Xiaoqun Xu, Junfu Wang |
Abstract |
MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression post-transcriptionally. They are involved in almost all cellular processes, and many have been described as potential oncogenes or tumor suppressors. MicroRNA-373 (miR-373), which was first identified as a human embryonic stem cell (ESC)-specific miRNA, is suggested to be implicated in the regulation of cell proliferation, apoptosis, senescence, migration and invasion, as well as DNA damage repair following hypoxia stress. Deregulation of miR-373 has been demonstrated in a number of cancers, whether it acts as an oncogene or a tumor suppressor, however, seems to be context dependent. In this review, we focus on the diverse functions of miR-373 and its implication in cancers. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Luxembourg | 1 | 2% |
Unknown | 52 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 12 | 23% |
Student > Master | 11 | 21% |
Student > Bachelor | 9 | 17% |
Researcher | 7 | 13% |
Other | 2 | 4% |
Other | 3 | 6% |
Unknown | 9 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 13 | 25% |
Agricultural and Biological Sciences | 10 | 19% |
Medicine and Dentistry | 9 | 17% |
Nursing and Health Professions | 2 | 4% |
Immunology and Microbiology | 2 | 4% |
Other | 6 | 11% |
Unknown | 11 | 21% |