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The expression of CXCL13 and its relation to unfavorable clinical characteristics in young breast cancer

Overview of attention for article published in Journal of Translational Medicine, May 2015
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  • Good Attention Score compared to outputs of the same age (70th percentile)

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2 tweeters
1 patent


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33 Mendeley
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The expression of CXCL13 and its relation to unfavorable clinical characteristics in young breast cancer
Published in
Journal of Translational Medicine, May 2015
DOI 10.1186/s12967-015-0521-1
Pubmed ID

Lujia Chen, Zhongxi Huang, Guangyu Yao, Xiaoming Lyu, Jinbang Li, Xiaolei Hu, Yahong Cai, Wenji Li, Xin Li, Changsheng Ye


Young breast cancer occupies a higher and higher proportion of breast cancer, especially in Asia, and is associated with a more unfavorable prognosis compared with the disease arising in older women. However, the poor prognosis of young breast cancer cannot be fully explained by the clinical and molecular factors. This study investigated 1125 Chinese breast cancer patients diagnosed from 2009 to 2013. A data mining of gene expression profiles was performed for the young and older breast cancer patients, identifying significantly differentially expressed genes. Quantitative RT-PCR, Western blotting and immunohistochemistry assay were carried out for the clinical sample validations. The investigation firstly displayed that young patients (≤45 years) accounted for 47.6 % (535/1125) of breast cancer, and clinically associated with some unfavorable factors related to poor prognosis, such as invasive pathological type, high tumor grade, lymph node positive, ER negative and triple-negative subtype. Subsequently, 553 significantly differentially expressed genes were identified by the data mining. Of them, a set of genes related to immune function were observed to be up-regulated in young patients with breast cancer. Impressively, the CXCL13 (C-X-C motif chemokine 13) expression level showed the most significant difference (FC = 2.64, P = 8.2 × 10(-4)). Furthermore, the validations with clinical samples and correlation analysis demonstrated that CXCL13 was indeed highly expressed in young breast cancer and closely associated with some prognostic factors including lymph node positive and ER negative. This is the first to indicate the clinical relevance of CXCL13 to young breast cancer and represents a potential therapeutic target for young breast cancer.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 33 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 15%
Researcher 4 12%
Student > Ph. D. Student 4 12%
Student > Postgraduate 3 9%
Student > Doctoral Student 2 6%
Other 6 18%
Unknown 9 27%
Readers by discipline Count As %
Medicine and Dentistry 13 39%
Biochemistry, Genetics and Molecular Biology 5 15%
Agricultural and Biological Sciences 4 12%
Social Sciences 1 3%
Psychology 1 3%
Other 0 0%
Unknown 9 27%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 January 2018.
All research outputs
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Outputs from Journal of Translational Medicine
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Outputs of similar age
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Outputs of similar age from Journal of Translational Medicine
of 1 outputs
Altmetric has tracked 14,781,724 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 2,821 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.8. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 232,528 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them