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Characterization of TLR2, NOD2, and related cytokines in mammary glands infected by Staphylococcus aureus in a rat model

Overview of attention for article published in Acta Veterinaria Scandinavica, May 2015
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (69th percentile)

Mentioned by

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1 tweeter
patent
1 patent

Citations

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16 Dimensions

Readers on

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23 Mendeley
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Title
Characterization of TLR2, NOD2, and related cytokines in mammary glands infected by Staphylococcus aureus in a rat model
Published in
Acta Veterinaria Scandinavica, May 2015
DOI 10.1186/s13028-015-0116-0
Pubmed ID
Authors

Heng Wang, Guangtao Yu, Hui Yu, Mingjie Gu, Jun Zhang, Xia Meng, Zongping Liu, Changwei Qiu, Jianji Li

Abstract

Staphylococcus aureus causes subclinical mastitis as well as persistent and chronic infections in cattle. Bovine mastitis induced by S. aureus is often refractory to antibiotic treatment. Local innate immune defenses play an important role in eliminating the invading bacteria. TLR2 and NOD2 are important pathogen recognition receptors, but their functions have not been investigated in the context of early stages of mastitis. The present study examined TLR2, NOD2, and related cytokines in mammary glands infection induced by S. aureus at early stages in a rat mastitis model. All inoculated mammary glands developed mastitis. Acute changes were induced in mammary tissues infected with S. aureus at early stages and then chronic infections persisted until the end of the experiment. TLR2 and NOD2 mRNA expression increased significantly after inoculation with S. aureus. The expression levels of cytokine mRNAs, including TNF-α, IL-1β, IL-6, IL-10, and CXCL1, also increased. TGF-β1 expression was suppressed at early phase and IFN-γ mRNA expression increased significantly at a later stage. Mammary innate immune responses were activated after S. aureus inoculation. TLR2, NOD2, and inflammatory cytokines (TNF-α, IL-1β, IL-6, CXCL1, IL-10, TGF-β1, and IFN-γ) are involved in the response to mastitis induced by S. aureus.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 23 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 5 22%
Student > Bachelor 4 17%
Researcher 3 13%
Student > Ph. D. Student 2 9%
Librarian 1 4%
Other 3 13%
Unknown 5 22%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 6 26%
Agricultural and Biological Sciences 3 13%
Medicine and Dentistry 2 9%
Immunology and Microbiology 2 9%
Computer Science 1 4%
Other 2 9%
Unknown 7 30%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 June 2018.
All research outputs
#4,400,699
of 14,783,063 outputs
Outputs from Acta Veterinaria Scandinavica
#88
of 538 outputs
Outputs of similar age
#69,972
of 232,540 outputs
Outputs of similar age from Acta Veterinaria Scandinavica
#1
of 1 outputs
Altmetric has tracked 14,783,063 research outputs across all sources so far. This one has received more attention than most of these and is in the 69th percentile.
So far Altmetric has tracked 538 research outputs from this source. They receive a mean Attention Score of 2.9. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 232,540 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them