Title |
Humans as holobionts: implications for prevention and therapy
|
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Published in |
Microbiome, May 2018
|
DOI | 10.1186/s40168-018-0466-8 |
Pubmed ID | |
Authors |
Maarten van de Guchte, Hervé M. Blottière, Joël Doré |
Abstract |
The human gut microbiota is increasingly recognized for its important or even decisive role in health. As it becomes clear that microbiota and host mutually affect and depend on each other in an intimate relationship, a holistic view of the gut microbiota-host association imposes itself. Ideally, a stable state of equilibrium, homeostasis, is maintained and serves health, but signs are that perturbation of this equilibrium beyond the limits of resilience can propel the system into an alternative stable state, a pre-disease state, more susceptible to the development of chronic diseases. The microbiota-host equilibrium of a large and growing proportion of individuals in Western society may represent such a pre-disease state and explain the explosive development of chronic diseases such as inflammatory bowel disease, obesity, and other inflammatory diseases. These diseases themselves represent other alternative stable states again and are therefore hard to cure. The holistic view of the microbiota-host association where feedback loops between microbiota and host are thought to maintain the system in a stable state-be it a healthy, pre-disease, or disease state-implies that integrated approaches, addressing host processes and microbiota, should be used to treat or prevent (pre-)disease. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 12 | 26% |
France | 7 | 15% |
Mexico | 2 | 4% |
Honduras | 1 | 2% |
Canada | 1 | 2% |
Germany | 1 | 2% |
Australia | 1 | 2% |
Chile | 1 | 2% |
India | 1 | 2% |
Other | 1 | 2% |
Unknown | 18 | 39% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 30 | 65% |
Scientists | 14 | 30% |
Practitioners (doctors, other healthcare professionals) | 1 | 2% |
Science communicators (journalists, bloggers, editors) | 1 | 2% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 228 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 39 | 17% |
Student > Ph. D. Student | 38 | 17% |
Researcher | 36 | 16% |
Student > Bachelor | 17 | 7% |
Student > Doctoral Student | 14 | 6% |
Other | 33 | 14% |
Unknown | 51 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 52 | 23% |
Biochemistry, Genetics and Molecular Biology | 35 | 15% |
Medicine and Dentistry | 19 | 8% |
Immunology and Microbiology | 18 | 8% |
Environmental Science | 11 | 5% |
Other | 34 | 15% |
Unknown | 59 | 26% |