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Association between BDNF levels and suicidal behaviour: a systematic review protocol

Overview of attention for article published in Systematic Reviews, April 2015
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Title
Association between BDNF levels and suicidal behaviour: a systematic review protocol
Published in
Systematic Reviews, April 2015
DOI 10.1186/s13643-015-0047-x
Pubmed ID
Authors

Rebecca Eisen, Stefan Perera, Monica Bawor, Laura Banfield, Rebecca Anglin, Luciano Minuzzi, Zainab Samaan

Abstract

Suicide is a worldwide public health concern that claims close to 1 million lives each year. Suicidal behaviour is a significant risk factor for completed suicide and is much more prevalent than completed suicide. Many internal and external factors contribute to the risk of suicidal behaviour. Recent research has focused on biological markers in suicide risk, including brain-derived neurotrophic factor (BDNF). BDNF is a protein involved in the growth, function, and maintenance of the nervous system. It has been implicated in psychiatric disorders and suicide. While some evidence suggests that reduced levels of BDNF are associated with suicide, the precise relationship has yet to be determined. The aim of this study is to review the literature examining the relationship between levels of BDNF and suicidal behaviour. A predefined search strategy will be implemented to search the following electronic databases: PubMed/MEDLINE, Excerpta Medica Database (EMBASE), PsycINFO, and Cumulative Index to Nursing and Allied Health Literature (CINAHL) from inception. The articles will be screened by two independent authors (RE and SP) using predetermined inclusion and exclusion criteria. Discrepancies will be resolved by consensus, or by a third author (ZS) in cases of disagreement. The primary outcome will be the association between levels of BDNF and suicidal behaviour. A meta-analysis will be conducted if appropriate. Quality of evidence and risk of bias will be evaluated. The findings of this review will assist in identifying and treating individuals at increased risk of suicide. PROSPERO CRD42015015871 .

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 48 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 5 10%
Student > Ph. D. Student 4 8%
Researcher 4 8%
Student > Bachelor 4 8%
Other 3 6%
Other 12 25%
Unknown 16 33%
Readers by discipline Count As %
Medicine and Dentistry 9 19%
Psychology 7 15%
Nursing and Health Professions 4 8%
Agricultural and Biological Sciences 4 8%
Neuroscience 3 6%
Other 6 13%
Unknown 15 31%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 May 2015.
All research outputs
#2,685,974
of 5,131,029 outputs
Outputs from Systematic Reviews
#322
of 432 outputs
Outputs of similar age
#97,143
of 172,491 outputs
Outputs of similar age from Systematic Reviews
#29
of 38 outputs
Altmetric has tracked 5,131,029 research outputs across all sources so far. This one is in the 47th percentile – i.e., 47% of other outputs scored the same or lower than it.
So far Altmetric has tracked 432 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 10.0. This one is in the 25th percentile – i.e., 25% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 172,491 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 38 others from the same source and published within six weeks on either side of this one. This one is in the 23rd percentile – i.e., 23% of its contemporaries scored the same or lower than it.