Title |
Bilirubin is independently associated with oxidized LDL levels in young obese patients
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Published in |
Diabetology & Metabolic Syndrome, January 2015
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DOI | 10.1186/1758-5996-7-4 |
Pubmed ID | |
Authors |
Henrique Nascimento, Ana Inês Alves, Susana Coimbra, Cristina Catarino, Diana Gomes, Elsa Bronze-da-Rocha, Elísio Costa, Petronila Rocha-Pereira, Luísa Aires, Jorge Mota, Helena Ferreira Mansilha, Carla Rêgo, Alice Santos-Silva, Luís Belo |
Abstract |
Bilirubin can prevent lipid oxidation in vitro, but the association in vivo with oxidized low-density lipoprotein (Ox-LDL) levels has been poorly explored. Our aim is to the association of Ox-LDL with total bilirubin (TB) levels and with variables related with metabolic syndrome and inflammation, in young obese individuals. 125 obese patients (13.4 years; 53.6% females) were studied. TB, lipid profile including Ox-LDL, markers of glucose metabolism, and levels of C-reactive protein (CRP) and adiponectin were determined. Anthropometric data was also collected. In all patients, Ox-LDL correlated positively with BMI, total cholesterol, LDLc, triglycerides (TG), CRP, glucose, insulin and HOMAIR; while inversely with TB and HDLc/Total cholesterol ratio (P < 0.05 for all). In multiple linear regression analysis, LDLc, TG, HDLc and TB levels were significantly associated with Ox-LDL (standardized Beta: 0.656, 0.293, -0.283, -0.164, respectively; P < 0.01 for all). After removing TG and HDLc from the analysis, HOMAIR was included in the regression model. In this new model, LDLc remained the best predictor of Ox-LDL levels (β = 0.665, P < 0.001), followed by TB (β = -0.202, P = 0.002) and HOMAIR (β = 0.163, P = 0.010). Lower bilirubin levels may contribute to increased LDL oxidation in obese children and adolescents, predisposing to increased cardiovascular risk. |
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