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Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis

Overview of attention for article published in Acta Neuropathologica Communications, May 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (86th percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

news
1 news outlet
twitter
2 tweeters

Citations

dimensions_citation
314 Dimensions

Readers on

mendeley
510 Mendeley
citeulike
1 CiteULike
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Title
Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis
Published in
Acta Neuropathologica Communications, May 2015
DOI 10.1186/s40478-015-0203-5
Pubmed ID
Authors

Inge R Holtman, Divya D Raj, Jeremy A Miller, Wandert Schaafsma, Zhuoran Yin, Nieske Brouwer, Paul D Wes, Thomas Möller, Marie Orre, Willem Kamphuis, Elly M Hol, Erik W G M Boddeke, Bart J L Eggen

Abstract

Microglia are tissue macrophages of the central nervous system that monitor brain homeostasis and react upon neuronal damage and stress. Aging and neurodegeneration induce a hypersensitive, pro-inflammatory phenotype, referred to as primed microglia. To determine the gene expression signature of priming, the transcriptomes of microglia in aging, Alzheimer's disease (AD), and amyotrophic lateral sclerosis (ALS) mouse models were compared using Weighted Gene Co-expression Network Analysis (WGCNA). A highly consistent consensus transcriptional profile of up-regulated genes was identified, which prominently differed from the acute inflammatory gene network induced by lipopolysaccharide (LPS). Where the acute inflammatory network was significantly enriched for NF-κB signaling, the primed microglia profile contained key features related to phagosome, lysosome, antigen presentation, and AD signaling. In addition, specific signatures for aging, AD, and ALS were identified. Microglia priming induces a highly conserved transcriptional signature with aging- and disease-specific aspects.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 510 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 3 <1%
Spain 1 <1%
United Kingdom 1 <1%
Germany 1 <1%
Unknown 504 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 137 27%
Researcher 83 16%
Student > Master 59 12%
Student > Bachelor 58 11%
Student > Doctoral Student 34 7%
Other 70 14%
Unknown 69 14%
Readers by discipline Count As %
Neuroscience 132 26%
Agricultural and Biological Sciences 98 19%
Biochemistry, Genetics and Molecular Biology 78 15%
Medicine and Dentistry 45 9%
Immunology and Microbiology 20 4%
Other 48 9%
Unknown 89 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 May 2015.
All research outputs
#600,402
of 6,792,686 outputs
Outputs from Acta Neuropathologica Communications
#59
of 328 outputs
Outputs of similar age
#27,738
of 212,407 outputs
Outputs of similar age from Acta Neuropathologica Communications
#7
of 14 outputs
Altmetric has tracked 6,792,686 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 328 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.2. This one has done well, scoring higher than 79% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 212,407 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.