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Lycium barbarum polysaccharide protects HSF cells against ultraviolet-induced damage through the activation of Nrf2

Overview of attention for article published in Cellular & Molecular Biology Letters, May 2018
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Title
Lycium barbarum polysaccharide protects HSF cells against ultraviolet-induced damage through the activation of Nrf2
Published in
Cellular & Molecular Biology Letters, May 2018
DOI 10.1186/s11658-018-0084-2
Pubmed ID
Authors

Bihua Liang, Liqian Peng, Runxiang Li, Huaping Li, Ziyin Mo, Xinyue Dai, Na Jiang, Qing Liu, Erting Zhang, Huiyan Deng, Zhenjie Li, Huilan Zhu

Abstract

Lycium barbarum polysaccharide (LBP) is considered an antioxidant agent. NF-E2-related factor-2 (Nrf2) is an important regulator for protection against UV damage. In this study, we verified the performance of LBP and the correlation between LBP and Nrf2. HSF cells were treated with LBP to determine dose and time dependencies. An antioxidant response element (ARE) reporter was designed to monitor the activity of the Nrf2 antioxidant pathway. For HSF cells, the optimal LBP treatment was 300 μg/ml for 3 h. The ARE-reporter assay showed that LBP could increase the robustness of p-Nrf2. Treatments with genistein and LY294002 reduced of nuclear p-Nrf2 after 24 h. LBP increased the level of nuclear Nrf2, which functions by both phosphorylation and nuclear translocation. Silencing Nrf2 led to increased reactive oxygen species (ROS) levels, lower cell viability, and decreased superoxide dismutase (SOD) and glutathione peroxidase (GSP-PX) levels. This induced a higher level of lipid peroxide (LPO). However, LBP could decrease the levels of ROS and LPO and enhance the levels of SOD and GSP-PX. LBP protects HSF cells against UV damage via the regulation of Nrf2.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 16 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 16 100%

Demographic breakdown

Readers by professional status Count As %
Other 3 19%
Student > Bachelor 2 13%
Researcher 2 13%
Lecturer 1 6%
Student > Ph. D. Student 1 6%
Other 1 6%
Unknown 6 38%
Readers by discipline Count As %
Medicine and Dentistry 3 19%
Biochemistry, Genetics and Molecular Biology 2 13%
Agricultural and Biological Sciences 1 6%
Nursing and Health Professions 1 6%
Sports and Recreations 1 6%
Other 1 6%
Unknown 7 44%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 October 2018.
All research outputs
#17,601,247
of 21,777,067 outputs
Outputs from Cellular & Molecular Biology Letters
#212
of 424 outputs
Outputs of similar age
#228,317
of 297,577 outputs
Outputs of similar age from Cellular & Molecular Biology Letters
#1
of 1 outputs
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So far Altmetric has tracked 424 research outputs from this source. They receive a mean Attention Score of 2.2. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
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