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The anti-inflammatory and antioxidant activity of 25 plant species used traditionally to treat pain in southern African

Overview of attention for article published in BMC Complementary Medicine and Therapies, May 2015
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Title
The anti-inflammatory and antioxidant activity of 25 plant species used traditionally to treat pain in southern African
Published in
BMC Complementary Medicine and Therapies, May 2015
DOI 10.1186/s12906-015-0669-5
Pubmed ID
Authors

Salmon A. Adebayo, Jean P. Dzoyem, Leshweni J. Shai, Jacobus N. Eloff

Abstract

Inflammation is a common risk factor in the pathogenesis of conditions such as infections, arthritis, type 2 diabetes mellitus, obesity and cancer. An ethnobotanical survey of medicinal plants used traditionally to treat inflammation and related disorders such as pain, arthritis and stomach aches in southern Africa led to the selection of 25 plant species used in this study. The antioxidant activities of acetone extracts were determined by measuring the free radical scavenging activity and ferric reducing ability, respectively. The anti-inflammatory activities of the extracts were determined by measuring the inhibitory effect of the extracts on the activities of the pro-inflammatory enzyme, lipoxygenase and inducible nitric oxide synthase. Extracts of Peltophorum africanum had good antioxidant activity with IC50 values of 4.67 ± 0.31 μg/mL and 7.71 ± 0.36 μg/mL compared to that of the positive control ascorbic acid (2.92 ± 0.14 μg/mL and 13.57 ± 0.44 μg/mL), using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging and 2,2'-azinobis (3-ethylbenzthiazoline-6-sulphonic acid (ABTS) methods, respectively. The metabolism of linoleic acid to leukotriene derivatives by 15-lipoxygenase (15-LOX) was also inhibited by the crude acetone extracts of Peltophorum africanum (IC50 = 12.42 μg/mL), Zanthoxylum capense (IC50 = 14.92 μg/mL) compared to the positive control quercetin (IC50 = 8.75 μg/mL). There was a poor correlation between the flavonoid content and 15-LOX inhibition by the extracts (R(2) = 0.05), indicating that flavonoids are not involved in LOX inhibition. Extracts of Clausena anisata, at a concentration of 6.25 μg/mL inhibited nitric oxide production by RAW 264.7 macrophage cell lines in vitro by 96 %. The extracts of Zanthoxylum capense were the least cytotoxic (IC50 > 1000 μg/mL) when the extract toxicity was determined against Vero (African green Monkey) kidney cell lines. Some plant species used traditionally to treat pain have reasonable anti-inflammatory activity and flavonoids are probably not involved in this process.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 303 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Ecuador 1 <1%
Mauritius 1 <1%
South Africa 1 <1%
Unknown 300 99%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 50 17%
Student > Master 33 11%
Student > Bachelor 31 10%
Researcher 29 10%
Student > Doctoral Student 21 7%
Other 44 15%
Unknown 95 31%
Readers by discipline Count As %
Agricultural and Biological Sciences 56 18%
Pharmacology, Toxicology and Pharmaceutical Science 35 12%
Medicine and Dentistry 30 10%
Biochemistry, Genetics and Molecular Biology 27 9%
Chemistry 15 5%
Other 37 12%
Unknown 103 34%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 November 2015.
All research outputs
#13,436,543
of 22,807,037 outputs
Outputs from BMC Complementary Medicine and Therapies
#1,509
of 3,630 outputs
Outputs of similar age
#126,743
of 266,724 outputs
Outputs of similar age from BMC Complementary Medicine and Therapies
#29
of 81 outputs
Altmetric has tracked 22,807,037 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,630 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.5. This one has gotten more attention than average, scoring higher than 56% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,724 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 81 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.