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The impact of severe haemophilia and the presence of target joints on health-related quality-of-life

Overview of attention for article published in Health and Quality of Life Outcomes, May 2018
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Title
The impact of severe haemophilia and the presence of target joints on health-related quality-of-life
Published in
Health and Quality of Life Outcomes, May 2018
DOI 10.1186/s12955-018-0908-9
Pubmed ID
Authors

Jamie O’Hara, Shaun Walsh, Charlotte Camp, Giuseppe Mazza, Liz Carroll, Christina Hoxer, Lars Wilkinson

Abstract

Joint damage remains a major complication associated with haemophilia and is widely accepted as one of the most debilitating symptoms for persons with severe haemophilia. The aim of this study is to describe how complications of haemophilia such as target joints influence health-related quality of life (HRQOL). Data on hemophilia patients without inhibitors were drawn from the 'Cost of Haemophilia across Europe - a Socioeconomic Survey' (CHESS) study, a cost-of-illness assessment in severe haemophilia A and B across five European countries (France, Germany, Italy, Spain, and the UK). Physicians provided clinical and sociodemographic information for 1285 adult patients, 551 of whom completed corresponding questionnaires, including EQ-5D. A generalised linear model was developed to investigate the relationship between EQ-5D index score and target joint status (defined in the CHESS study as areas of chronic synovitis), adjusted for patient covariates including socio-demographic characteristics and comorbidities. Five hundred and fifteen patients (42% of the sample) provided an EQ-5D response; a total of 692 target joints were recorded across the sample. Mean EQ-5D index score for patients with no target joints was 0.875 (standard deviation [SD] 0.179); for patients with one or more target joints, mean index score was 0.731 (SD 0.285). Compared to having no target joints, having one or more target joints was associated with lower index scores (average marginal effect (AME) -0.120; SD 0.0262; p < 0.000). This study found that the presence of chronic synovitis has a significant negative impact on HRQOL for adults with severe haemophilia. Prevention, early diagnosis and treatment of target joints should be an important consideration for clinicians and patients when managing haemophilia.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 70 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 70 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 11 16%
Student > Master 10 14%
Other 8 11%
Student > Bachelor 8 11%
Student > Ph. D. Student 4 6%
Other 9 13%
Unknown 20 29%
Readers by discipline Count As %
Medicine and Dentistry 19 27%
Economics, Econometrics and Finance 7 10%
Nursing and Health Professions 5 7%
Pharmacology, Toxicology and Pharmaceutical Science 3 4%
Biochemistry, Genetics and Molecular Biology 2 3%
Other 10 14%
Unknown 24 34%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 May 2018.
All research outputs
#11,778,720
of 15,442,255 outputs
Outputs from Health and Quality of Life Outcomes
#1,050
of 1,660 outputs
Outputs of similar age
#192,287
of 278,063 outputs
Outputs of similar age from Health and Quality of Life Outcomes
#1
of 1 outputs
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