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The utility of human fallopian tube mucosa as a novel source of multipotent stem cells for the treatment of autologous reproductive tract injury

Overview of attention for article published in Stem Cell Research & Therapy, May 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (78th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (64th percentile)

Mentioned by

news
1 news outlet

Citations

dimensions_citation
18 Dimensions

Readers on

mendeley
33 Mendeley
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Title
The utility of human fallopian tube mucosa as a novel source of multipotent stem cells for the treatment of autologous reproductive tract injury
Published in
Stem Cell Research & Therapy, May 2015
DOI 10.1186/s13287-015-0094-1
Pubmed ID
Authors

Jiaojiao Wang, Yong Zhao, Xiaoyun Wu, Shande Yin, Yunhai Chuai, Aiming Wang

Abstract

Fallopian tube, which is normally discarded in surgical procedures, is proved to be a source of mesenchymal stem cells with increasing evidence; however, fallopian tube mucosa, which can be acquired via non-invasive procedures, is a previously unknown source of mesenchymal stem cells. In the present study we explored the existence of MSCs in the human fallopian tube mucosa and we also compared multipotent stem cells derived from fallopian tubes and fallopian tube mucosa according to their biological characteristics and therapeutic potential for treatment of autologous reproductive tract injury. Cells isolated from human fallopian tubes and fallopian tube mucosa were expanded and characterised by flow cytometry. The proliferative capacity of both cell types was measured by performing colony-forming unit-fibroblast and CCK-8 assays. Both cell types underwent in vitro adipogenic- chondrogenic- and osteogenic- differentiation. The expression of osteocyte-, adipocyte- and chondrocyte-related genes in the differentiated cell lineages was assessed by RT-PCR. The secretion of growth factors and immunomodulatory cytokines by both cell types were measured by enzyme-linked immunosorbent assays. We found that MSCs are existed in the fallopian tube mucosa. The comparison between human fallopian tube mesenchymal stem cells (hFTMSCs) and human fallopian tube mesenchymal stem cells (hFMMSCs) showed that hFTMSCs had a stronger proliferative capacity and shorter duplication time than hFMMSCs. Both cell types could be differentiated into adipocytes, osteoblasts or chondrocytes in vitro. Real-time PCR analysis demonstrated that hFTMSCs displayed increased expression of osteogenic-specific genes compared with hFMMSCs but the two types of cells showed no significant increase in the mRNA expression of adipogenic-specific or chondrogenic-specific genes. hFMMSCs and hFTMSCs robustly produced a variety of growth factors and immunomodulatory cytokines. Human fallopian tube mucosa is a novel source of multipotent cells. hFMMSCs demonstrated stronger proliferative capacity and superior secretion of growth factors and immunomodulatory cytokines than hFTMSCs, which make them a better source of stem cells for the treatment of autologous reproductive tract injury. Compared to fallopian tube, Fallopian tube mucosa have a more wide-ranging sources and applications and it can realize autologous transplantation.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 33 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
Unknown 32 97%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 7 21%
Student > Master 6 18%
Researcher 6 18%
Student > Doctoral Student 3 9%
Professor > Associate Professor 3 9%
Other 4 12%
Unknown 4 12%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 9 27%
Medicine and Dentistry 7 21%
Agricultural and Biological Sciences 3 9%
Engineering 3 9%
Immunology and Microbiology 2 6%
Other 4 12%
Unknown 5 15%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 May 2015.
All research outputs
#4,174,660
of 22,807,037 outputs
Outputs from Stem Cell Research & Therapy
#412
of 2,418 outputs
Outputs of similar age
#53,276
of 266,745 outputs
Outputs of similar age from Stem Cell Research & Therapy
#19
of 56 outputs
Altmetric has tracked 22,807,037 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,418 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.0. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,745 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 78% of its contemporaries.
We're also able to compare this research output to 56 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.