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Osthole improves collagen-induced arthritis in a rat model through inhibiting inflammation and cellular stress

Overview of attention for article published in Cellular & Molecular Biology Letters, May 2018
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Title
Osthole improves collagen-induced arthritis in a rat model through inhibiting inflammation and cellular stress
Published in
Cellular & Molecular Biology Letters, May 2018
DOI 10.1186/s11658-018-0086-0
Pubmed ID
Authors

Renguo Xu, Zhen Liu, Jiande Hou, Tao Huang, Ming Yang

Abstract

Osthole is a natural product that has multiple bioactive functions and has been reported to exert potent immunosuppressive effects. However, the therapeutic effect of osthole on arthritis has not been explored. In the present study, a collagen-induced arthritis rat model, IL-1β-stimulated SW982 cells, and RA-like fibroblast-like synoviocytes (FLS) were employed to investigate the effect and possible mechanism of osthole on arthritis in vivo and in vitro. 20 and 40 mg/kg osthole significantly alleviated collagen-induced arthritic symptoms based on histopathology and clinical arthritis scores, and improved erosion using HE staining. 20 and 40 mg/kg osthole decreased the level of IL-1β, TNF-α and IL-6 in rats and ameliorated oxidative stress in serum evaluated using ELISA kits. In addition, treatment with 50 and 100 μM osthole for 48 h inhibited 10 ng/ml IL-1β-stimulated proliferation and migration of SW982, and significantly inhibited the expression of matrix metalloproteinases, such as MMP-1, MMP-3 and MMP-13, as detected by western blot. 50 and 100 μM osthole also blocked the generation of IL-6 and TNF-α in IL-1β-stimulated SW982 cells. The NF-κB and MAPK pathways were also inhibited by osthole in IL-1β-treated SW982 cells. These results collectively demonstrated that osthole improves collagen-induced arthritis in a rat model and IL-1β-treated SW982 cells through inhibiting inflammation and cellular stress in vivo and in vitro, and osthole might be a promising therapeutic agent for RA.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 15 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 3 20%
Student > Bachelor 3 20%
Student > Master 2 13%
Student > Ph. D. Student 1 7%
Researcher 1 7%
Other 0 0%
Unknown 5 33%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 5 33%
Pharmacology, Toxicology and Pharmaceutical Science 2 13%
Nursing and Health Professions 1 7%
Medicine and Dentistry 1 7%
Unknown 6 40%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 May 2018.
All research outputs
#10,284,104
of 12,886,920 outputs
Outputs from Cellular & Molecular Biology Letters
#86
of 197 outputs
Outputs of similar age
#201,478
of 269,061 outputs
Outputs of similar age from Cellular & Molecular Biology Letters
#1
of 1 outputs
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