Title |
tcR: an R package for T cell receptor repertoire advanced data analysis
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Published in |
BMC Bioinformatics, May 2015
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DOI | 10.1186/s12859-015-0613-1 |
Pubmed ID | |
Authors |
Vadim I. Nazarov, Mikhail V. Pogorelyy, Ekaterina A. Komech, Ivan V. Zvyagin, Dmitry A. Bolotin, Mikhail Shugay, Dmitry M. Chudakov, Yury B. Lebedev, Ilgar Z. Mamedov |
Abstract |
The Immunoglobulins (IG) and the T cell receptors (TR) play the key role in antigen recognition during the adaptive immune response. Recent progress in next-generation sequencing technologies has provided an opportunity for the deep T cell receptor repertoire profiling. However, a specialised software is required for the rational analysis of massive data generated by next-generation sequencing. Here we introduce tcR, a new R package, representing a platform for the advanced analysis of T cell receptor repertoires, which includes diversity measures, shared T cell receptor sequences identification, gene usage statistics computation and other widely used methods. The tool has proven its utility in recent research studies. tcR is an R package for the advanced analysis of T cell receptor repertoires after primary TR sequences extraction from raw sequencing reads. The stable version can be directly installed from The Comprehensive R Archive Network ( http://cran.r-project.org/mirrors.html ). The source code and development version are available at tcR GitHub ( http://imminfo.github.io/tcr/ ) along with the full documentation and typical usage examples. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 3 | 25% |
United Kingdom | 1 | 8% |
Unknown | 8 | 67% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 7 | 58% |
Scientists | 5 | 42% |
Mendeley readers
Geographical breakdown
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Germany | 2 | <1% |
Netherlands | 1 | <1% |
Austria | 1 | <1% |
Australia | 1 | <1% |
United States | 1 | <1% |
Unknown | 272 | 98% |
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Readers by professional status | Count | As % |
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Researcher | 67 | 24% |
Student > Ph. D. Student | 51 | 18% |
Student > Master | 35 | 13% |
Student > Bachelor | 21 | 8% |
Student > Doctoral Student | 14 | 5% |
Other | 45 | 16% |
Unknown | 45 | 16% |
Readers by discipline | Count | As % |
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Agricultural and Biological Sciences | 77 | 28% |
Biochemistry, Genetics and Molecular Biology | 53 | 19% |
Medicine and Dentistry | 35 | 13% |
Immunology and Microbiology | 33 | 12% |
Computer Science | 11 | 4% |
Other | 19 | 7% |
Unknown | 50 | 18% |