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Severe malaria in children leads to a significant impairment of transitory otoacoustic emissions - a prospective multicenter cohort study

Overview of attention for article published in BMC Medicine, May 2015
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  • Good Attention Score compared to outputs of the same age (73rd percentile)

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Title
Severe malaria in children leads to a significant impairment of transitory otoacoustic emissions - a prospective multicenter cohort study
Published in
BMC Medicine, May 2015
DOI 10.1186/s12916-015-0366-8
Pubmed ID
Authors

Joachim Schmutzhard, Peter Lackner, Raimund Helbok, Helene Verena Hurth, Fabian Cedric Aregger, Veronika Muigg, Josua Kegele, Sebastian Bunk, Lukas Oberhammer, Natalie Fischer, Leyla Pinggera, Allan Otieno, Bernards Ogutu, Tsiri Agbenyega, Daniel Ansong, Ayola A. Adegnika, Saadou Issifou, Patrick Zorowka, Sanjeev Krishna, Benjamin Mordmüller, Erich Schmutzhard, Peter Kremsner

Abstract

Severe malaria may influence inner ear function, although this possibility has not been examined prospectively. In a retrospective analysis, hearing impairment was found in 9 of 23 patients with cerebral malaria. An objective method to quickly evaluate the function of the inner ear are the otoacoustic emissions. Negative transient otoacoustic emissions are associated with a threshold shift of 20 dB and above. This prospective multicenter study analyses otoacoustic emissions in patients with severe malaria up to the age of 10 years. In three study sites (Ghana, Gabon, Kenya) 144 patients with severe malaria and 108 control children were included. All malaria patients were treated with parental artesunate. In the control group, 92.6 % (n = 108, 95 % confidence interval 86.19-6.2 %) passed otoacoustic emission screening. In malaria patients, 58.5 % (n = 94, malaria vs controls p < 0.001, 95 % confidence interval 48.4-67.9 %) passed otoacoustic emission screening at the baseline measurement. The value increased to 65.2 % (n = 66, p < 0.001, 95 % confidence interval 53.1-75.5 %) at follow up 14-28 days after diagnosis of malaria. The study population was divided into severe non-cerebral malaria and severe malaria with neurological symptoms (cerebral malaria). Whereas otoacoustic emissions in severe malaria improved to a passing percentage of 72.9 % (n = 48, 95 % confidence interval 59-83.4 %) at follow-up, the patients with cerebral malaria showed a drop in the passing percentage to 33 % (n = 18) 3-7 days after diagnosis. This shows a significant impairment in the cerebral malaria group (p = 0.012 at days 3-7, 95 % confidence interval 16.3-56.3 %; p = 0.031 at day 14-28, 95 % confidence interval 24.5-66.3 %). The presented data show that 40 % of children have involvement of the inner ear early in severe malaria. In children, audiological screening after severe malaria infection is not currently recommended, but is worth investigating in larger studies.

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X Demographics

The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 60 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Portugal 1 2%
Australia 1 2%
Unknown 57 95%

Demographic breakdown

Readers by professional status Count As %
Student > Master 12 20%
Student > Bachelor 9 15%
Researcher 7 12%
Student > Postgraduate 7 12%
Student > Ph. D. Student 4 7%
Other 11 18%
Unknown 10 17%
Readers by discipline Count As %
Medicine and Dentistry 25 42%
Nursing and Health Professions 5 8%
Agricultural and Biological Sciences 5 8%
Social Sciences 4 7%
Computer Science 2 3%
Other 9 15%
Unknown 10 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 July 2015.
All research outputs
#6,034,064
of 22,807,037 outputs
Outputs from BMC Medicine
#2,309
of 3,421 outputs
Outputs of similar age
#70,686
of 266,679 outputs
Outputs of similar age from BMC Medicine
#59
of 79 outputs
Altmetric has tracked 22,807,037 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 3,421 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 43.6. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,679 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 79 others from the same source and published within six weeks on either side of this one. This one is in the 25th percentile – i.e., 25% of its contemporaries scored the same or lower than it.