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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Estrogen induces St6gal1 expression and increases IgG sialylation in mice and patients with rheumatoid arthritis: a potential explanation for the increased risk of rheumatoid arthritis in postmenopausal women
|
|---|---|
| Published in |
Arthritis Research & Therapy, May 2018
|
| DOI | 10.1186/s13075-018-1586-z |
| Pubmed ID | |
| Authors |
Cecilia Engdahl, Albert Bondt, Ulrike Harre, Jasmin Raufer, René Pfeifle, Alessandro Camponeschi, Manfred Wuhrer, Michaela Seeling, Inga-Lill Mårtensson, Falk Nimmerjahn, Gerhard Krönke, Hans U. Scherer, Helena Forsblad-d’Elia, Georg Schett |
| Abstract |
Rheumatoid arthritis (RA) preferentially affects women, with the peak incidence coinciding with estrogen decrease in menopause. Estrogen (E2) may therefore have intrinsic immune-regulatory properties that vanish with menopause. Fc sialylation is a crucial factor determining the inflammatory effector function of antibodies. We therefore analyzed whether E2 affects immunoglobulin G (IgG) sialylation. Postmenopausal (ovariectomized) mice were immunized with ovalbumin and treated with E2 or vehicle. Total and ovalbumin-specific IgG concentrations, sialylation, and Fcγ receptor expression were analyzed. Postmenopausal women with RA receiving hormone replacement therapy, including E2, or no treatment were analyzed for IgG sialylation. Furthermore, effects of E2 on the expression of the sialylation enzyme β-galactoside α2,6-sialyltransferase 1 (St6Gal1) were studied in mouse and human antibody-producing cells. E2 treatment significantly increased Fc sialylation of total and ovalbumin-specific IgG in postmenopausal mice. Furthermore, E2 led to increased expression of inhibitory Fcγ receptor IIb on bone marrow leukocytes. Treatment with E2 also increased St6Gal1 expression in mouse and human antibody-producing cells, providing a mechanistic explanation for the increase in IgG-Fc sialylation. In postmenopausal women with RA, treatment with E2 significantly increased the Fc sialylation of IgG. E2 induces anti-inflammatory effector functions in IgG by inducing St6Gal1 expression in antibody-producing cells and by increasing Fc sialylation. These observations provide a mechanistic explanation for the increased risk of RA in conditions with low estrogen levels such as menopause. |
X Demographics
The data shown below were collected from the profiles of 39 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 5 | 13% |
| Mexico | 3 | 8% |
| United States | 2 | 5% |
| United Kingdom | 2 | 5% |
| Chile | 1 | 3% |
| Canada | 1 | 3% |
| Colombia | 1 | 3% |
| Qatar | 1 | 3% |
| Venezuela, Bolivarian Republic of | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 21 | 54% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 24 | 62% |
| Scientists | 9 | 23% |
| Science communicators (journalists, bloggers, editors) | 3 | 8% |
| Practitioners (doctors, other healthcare professionals) | 3 | 8% |
Mendeley readers
The data shown below were compiled from readership statistics for 81 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 81 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 14% |
| Student > Bachelor | 11 | 14% |
| Student > Master | 7 | 9% |
| Researcher | 7 | 9% |
| Student > Postgraduate | 4 | 5% |
| Other | 10 | 12% |
| Unknown | 31 | 38% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 13 | 16% |
| Immunology and Microbiology | 10 | 12% |
| Medicine and Dentistry | 9 | 11% |
| Agricultural and Biological Sciences | 4 | 5% |
| Nursing and Health Professions | 3 | 4% |
| Other | 6 | 7% |
| Unknown | 36 | 44% |
Attention Score in Context
This research output has an Altmetric Attention Score of 40. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 March 2023.
All research outputs
#1,022,496
of 25,382,440 outputs
Outputs from Arthritis Research & Therapy
#83
of 3,381 outputs
Outputs of similar age
#22,405
of 338,899 outputs
Outputs of similar age from Arthritis Research & Therapy
#2
of 56 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,381 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one has done particularly well, scoring higher than 97% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 338,899 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 56 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.