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Anti-Brucella activity of Caryopteris mongolica Bunge root extract against Brucella melitensis infection in mice

Overview of attention for article published in BMC Complementary Medicine and Therapies, May 2018
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  • Above-average Attention Score compared to outputs of the same age and source (51st percentile)

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Title
Anti-Brucella activity of Caryopteris mongolica Bunge root extract against Brucella melitensis infection in mice
Published in
BMC Complementary Medicine and Therapies, May 2018
DOI 10.1186/s12906-018-2220-y
Pubmed ID
Authors

Tsevelmaa N, Narangerel B, Odgerel O, Dariimaa D, Batkhuu J

Abstract

The current treatment for human brucellosis requires a combination of antibiotics for long periods of time, and the reported incidence and prevalence of the disease vary widely in nomadic livestock of Mongolia. The objective of the present study was to evaluate the in vivo antibacterial activity of the C. mongolica root extract against B. melitensis. In this study, we used of 6 groups of mice (n = 5). Five groups of BALB/c mice were inoculated intraperitoneally with the M16 strain of B. melintensis, as follows: (i) one group was used for pretreatment monitoring; (ii) the control group was administered 2% Tween 80 and was used as the non-treatment group; and the other three groups were treated with one oral gavage per day for 21 days with (iii) doxycycline (2 mg/day), (iv) doxycycline (1 mg/day) with root extract (20 mg/day), and (v) C. mongolica root extract (20 mg/day). The one group that was kept non-infected was used as a healthy control group. This study demonstrated that daily treatment with doxycycline alone and in combination with C. mongolica root extract significantly reduced splenic infection at the end of treatment. However, the spleen index of both the doxycycline-treated and the combination-treated groups of mice decreased by approximately 50% compared to that of the healthy control mouse group. Treatment with the C. mongolica root extract resulted in a 1.47log reduction in splenic infection compared to the non-treatment group, and the spleen index of the C. mongolica-treated group of mice was the same as that of the normal mouse group. In all treatment groups, neutrophil phagocytic activity significantly decreased, and all treatment groups demonstrated splenic regeneration. The present study showed that the C. mongolica root extract may be useful in the treatment of brucellosis patients, in combination with doxycycline or other antibiotics, to reduce the toxicity of high-dosage antibiotics, to prevent the development of antibiotic resistance and to prevent Brucella infection.

X Demographics

X Demographics

The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 23 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 4 17%
Researcher 4 17%
Student > Ph. D. Student 1 4%
Student > Doctoral Student 1 4%
Student > Postgraduate 1 4%
Other 0 0%
Unknown 12 52%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 4 17%
Biochemistry, Genetics and Molecular Biology 3 13%
Pharmacology, Toxicology and Pharmaceutical Science 1 4%
Nursing and Health Professions 1 4%
Agricultural and Biological Sciences 1 4%
Other 2 9%
Unknown 11 48%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 January 2019.
All research outputs
#15,508,366
of 23,047,237 outputs
Outputs from BMC Complementary Medicine and Therapies
#2,057
of 3,647 outputs
Outputs of similar age
#208,063
of 326,458 outputs
Outputs of similar age from BMC Complementary Medicine and Therapies
#37
of 88 outputs
Altmetric has tracked 23,047,237 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,647 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.7. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 326,458 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 88 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.