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Adolescent endogenous sex hormones and breast density in early adulthood

Overview of attention for article published in Breast Cancer Research, June 2015
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Title
Adolescent endogenous sex hormones and breast density in early adulthood
Published in
Breast Cancer Research, June 2015
DOI 10.1186/s13058-015-0581-4
Pubmed ID
Authors

Seungyoun Jung, Brian L. Egleston, D. Walt Chandler, Linda Van Horn, Nola M. Hylton, Catherine C. Klifa, Norman L. Lasser, Erin S. LeBlanc, Kenneth Paris, John A. Shepherd, Linda G. Snetselaar, Frank Z. Stanczyk, Victor J. Stevens, Joanne F. Dorgan

Abstract

During adolescence the breasts undergo rapid growth and development under the influence of sex hormones. Although the hormonal etiology of breast cancer is hypothesized, it remains unknown whether adolescent sex hormones are associated with adult breast density, which is a strong risk factor for breast cancer. Percentage of dense breast volume (%DBV) was measured in 2006 by magnetic resonance imaging in 177 women aged 25-29 years who had participated in the Dietary Intervention Study in Children from 1988-1997. They had sex hormones and sex hormone binding globulin (SHBG) measured in serum collected on 1-5 occasions between 8 and 17 years of age. Multivariable linear mixed-effect regression models were used to evaluate the associations of adolescent sex hormones and SHBG with %DBV. Dehydroepiandrosterone sulfate (DHEAS) and SHBG measured in premenarche serum samples were significantly positively associated with %DBV (all P trend ≤ 0.03) but not when measured in postmenarche samples (all P trend ≥ 0.42). The multivariable geometric mean of %DBV across quartiles of premenarcheal DHEAS and SHBG increased from 16.7% to 22.1% and from 14.1% to 24.3%, respectively. Estrogens, progesterone, androstenedione, and testosterone in pre or postmenarche serum samples were not associated with %DBV (all P trend ≥ 0.16). Our results suggest that higher premenarcheal DHEAS and SHBG levels are associated with higher %DBV in young women. Whether this association translates into an increased risk of breast cancer later in life is currently unknown. ClinicalTrials.gov Identifier, NCT00458588 April 9, 2007 ; NCT00000459 October 27, 1999.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Unknown 58 98%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 8 14%
Student > Master 7 12%
Researcher 6 10%
Student > Ph. D. Student 5 8%
Student > Postgraduate 4 7%
Other 10 17%
Unknown 19 32%
Readers by discipline Count As %
Medicine and Dentistry 20 34%
Nursing and Health Professions 6 10%
Psychology 3 5%
Biochemistry, Genetics and Molecular Biology 2 3%
Engineering 2 3%
Other 5 8%
Unknown 21 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 June 2015.
All research outputs
#20,656,161
of 25,373,627 outputs
Outputs from Breast Cancer Research
#1,705
of 2,052 outputs
Outputs of similar age
#206,430
of 281,071 outputs
Outputs of similar age from Breast Cancer Research
#35
of 39 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
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