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A robust response to combination immune checkpoint inhibitor therapy in HPV-related small cell cancer: a case report

Overview of attention for article published in Journal for Immunotherapy of Cancer, May 2018
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (52nd percentile)

Mentioned by

twitter
6 tweeters

Citations

dimensions_citation
19 Dimensions

Readers on

mendeley
37 Mendeley
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Title
A robust response to combination immune checkpoint inhibitor therapy in HPV-related small cell cancer: a case report
Published in
Journal for Immunotherapy of Cancer, May 2018
DOI 10.1186/s40425-018-0348-4
Pubmed ID
Authors

Won Jin Ho, Lisa Rooper, Sarah Sagorsky, Hyunseok Kang

Abstract

Human papillomavirus-related small cell carcinoma of the head and neck is an extremely rare, aggressive subtype with poor outcomes. Therapeutic options are limited and are largely adopted from small cell lung cancer treatment paradigms. This report describes a 69-year old male who was diagnosed of HPV-related oropharyngeal cancer with mixed small cell and squamous cell pathology which was clinically aggressive and progressed through multimodal platinum-based therapies. Upon manifestation of worsening metastatic disease, the patient was initiated on a combination of ipilimumab and nivolumab. Within 2 months of starting immunotherapy, a robust partial response was observed. During the treatment course, the patient developed immune-related adverse effects including new diabetes mellitus, colitis, and hypothyroidism. The disease-specific survival was 26 months. Combination immunotherapy may be an attractive option for HPV-related small cell head and neck cancers resistant to other treatment modalities and thus warrants further evaluation.

Twitter Demographics

The data shown below were collected from the profiles of 6 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 37 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 6 16%
Student > Master 5 14%
Professor 3 8%
Researcher 3 8%
Student > Postgraduate 3 8%
Other 10 27%
Unknown 7 19%
Readers by discipline Count As %
Medicine and Dentistry 20 54%
Biochemistry, Genetics and Molecular Biology 2 5%
Unspecified 2 5%
Agricultural and Biological Sciences 2 5%
Computer Science 1 3%
Other 3 8%
Unknown 7 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 June 2018.
All research outputs
#7,051,790
of 13,034,624 outputs
Outputs from Journal for Immunotherapy of Cancer
#543
of 712 outputs
Outputs of similar age
#122,654
of 269,499 outputs
Outputs of similar age from Journal for Immunotherapy of Cancer
#1
of 1 outputs
Altmetric has tracked 13,034,624 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 712 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.7. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 269,499 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them