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Characterization of bursa subacromialis-derived mesenchymal stem cells

Overview of attention for article published in Stem Cell Research & Therapy, June 2015
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Title
Characterization of bursa subacromialis-derived mesenchymal stem cells
Published in
Stem Cell Research & Therapy, June 2015
DOI 10.1186/s13287-015-0104-3
Pubmed ID
Authors

Andre F. Steinert, Manuela Kunz, Patrick Prager, Sascha Göbel, Ludger Klein-Hitpass, Regina Ebert, Ulrich Nöth, Franz Jakob, Frank Gohlke

Abstract

The bursa subacromialis (BS) provides the gliding mechanism of the shoulder and regenerates itself after surgical removal. Thus we aimed explore the presence of mesenchymal stem cells (MSCs) within the human adult BS tissue and characterized the BS cells compared to MSCs from bone marrow (BMSCs) on a molecular level. BS cells were isolated by collagenase digest from BS tissues derived from patients with degenerative rotator cuff tears, and BMSCs were recovered by adherent culture from bone-marrow of patients with osteoarthritis of the hip. BS cells and BMSCs were compared upon their potential to proliferate and differentiate along chondrogenic, osteogenic and adipogenic lineages under specific culture conditions. Expression profiles of markers associated with mesenchymal phenotypes were comparatively evaluated by flow cytometry, immunohistochemistry, and whole genome array analyses. BS cells and BMSCs appeared mainly fibroblastic and revealed almost similar surface antigen expression profiles, which was CD44(+), CD73(+), CD90(+), CD105(+), CD106(+), STRO-1(+), CD14(-), CD31(-), CD34(-), CD45(-), CD144(-). Array analyses revealed 1969 genes upregulated and 1184 genes downregulated in BS cells vs. BMSCs, indicating a high level of transcriptome similarity. After 3 weeks of differentiation culture, BS cells and BMSCs showed a similar strong chondrogenic, adipogenic and osteogenic potential, as shown by histological, immunohistochemical and RT-PCR analyses in contrast to the respective negative controls. Our in vitro characterizations show that BS cells fulfill all characteristics of mesenchymal stem cells, and therefore merit further attention for the development of improved therapies for various shoulder pathologies.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Unknown 57 98%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 21%
Other 7 12%
Student > Ph. D. Student 5 9%
Student > Master 5 9%
Student > Postgraduate 4 7%
Other 12 21%
Unknown 13 22%
Readers by discipline Count As %
Medicine and Dentistry 28 48%
Engineering 4 7%
Biochemistry, Genetics and Molecular Biology 2 3%
Immunology and Microbiology 2 3%
Psychology 1 2%
Other 4 7%
Unknown 17 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 June 2015.
All research outputs
#2,746,134
of 5,187,004 outputs
Outputs from Stem Cell Research & Therapy
#273
of 452 outputs
Outputs of similar age
#98,527
of 175,002 outputs
Outputs of similar age from Stem Cell Research & Therapy
#23
of 34 outputs
Altmetric has tracked 5,187,004 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 452 research outputs from this source. They receive a mean Attention Score of 4.6. This one is in the 27th percentile – i.e., 27% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 175,002 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 34 others from the same source and published within six weeks on either side of this one. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.