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Nuclear myosin 1 contributes to a chromatin landscape compatible with RNA polymerase II transcription activation

Overview of attention for article published in BMC Biology, June 2015
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2 tweeters

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46 Mendeley
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Title
Nuclear myosin 1 contributes to a chromatin landscape compatible with RNA polymerase II transcription activation
Published in
BMC Biology, June 2015
DOI 10.1186/s12915-015-0147-z
Pubmed ID
Authors

Bader Almuzzaini, Aishe A. Sarshad, Ann-Kristin Östlund Farrants, Piergiorgio Percipalle

Abstract

Nuclear myosin 1c (NM1) is emerging as regulator of transcription and chromatin organization. Using chromatin immunoprecipitation and deep sequencing (ChIP-Seq) in combination with molecular analyses, here we investigated the global association of NM1 with the mammalian genome. Analysis of the ChIP-Seq data demonstrates that NM1 binds across the entire mammalian genome with occupancy peaks correlating with distributions of RNA Polymerase II (Pol II) and active epigenetic marks at class II genes promoters. In mouse embryonic fibroblasts subjected to RNAi mediated NM1 gene silencing, we show that NM1 synergizes with polymerase-associated actin to maintain active Pol II at the promoter. NM1 also co-localizes with the nucleosome remodeler SNF2h at class II promoters where they assemble together with WSTF as part of the B-WICH complex. A high resolution micrococcal nuclease (MNase) assay and quantitative real time PCR shows that this mechanism is required for local chromatin remodeling. Following B-WICH assembly, NM1 mediates physical recruitment of the histone acetyl transferase PCAF and the histone methyl transferase Set1/Ash2 to maintain and preserve H3K9acetylation and H3K4trimethylation for active transcription. We propose a novel genome-wide mechanism where myosin synergizes with Pol II-associated actin to link the polymerase machinery with permissive chromatin for transcription activation.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
France 1 2%
Unknown 45 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 24%
Researcher 8 17%
Student > Bachelor 6 13%
Student > Master 5 11%
Student > Doctoral Student 5 11%
Other 4 9%
Unknown 7 15%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 22 48%
Agricultural and Biological Sciences 15 33%
Psychology 1 2%
Medicine and Dentistry 1 2%
Unknown 7 15%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 March 2019.
All research outputs
#12,697,949
of 16,639,069 outputs
Outputs from BMC Biology
#1,313
of 1,442 outputs
Outputs of similar age
#153,052
of 238,725 outputs
Outputs of similar age from BMC Biology
#1
of 1 outputs
Altmetric has tracked 16,639,069 research outputs across all sources so far. This one is in the 20th percentile – i.e., 20% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,442 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 19.6. This one is in the 5th percentile – i.e., 5% of its peers scored the same or lower than it.
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We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them