Title |
Connectivity and circuitry in a dish versus in a brain
|
---|---|
Published in |
Alzheimer's Research & Therapy, June 2015
|
DOI | 10.1186/s13195-015-0129-y |
Pubmed ID | |
Authors |
Vorapin Chinchalongporn, Peter Koppensteiner, Deborah Prè, Wipawan Thangnipon, Leonilda Bilo, Ottavio Arancio |
Abstract |
In order to understand and find therapeutic strategies for neurological disorders, disease models that recapitulate the connectivity and circuitry of patients' brain are needed. Owing to many limitations of animal disease models, in vitro neuronal models using patient-derived stem cells are currently being developed. However, prior to employing neurons as a model in a dish, they need to be evaluated for their electrophysiological properties, including both passive and active membrane properties, dynamics of neurotransmitter release, and capacity to undergo synaptic plasticity. In this review, we survey recent attempts to study these issues in human induced pluripotent stem cell-derived neurons. Although progress has been made, there are still many hurdles to overcome before human induced pluripotent stem cell-derived neurons can fully recapitulate all of the above physiological properties of adult mature neurons. Moreover, proper integration of neurons into pre-existing circuitry still needs to be achieved. Nevertheless, in vitro neuronal stem cell-derived models hold great promise for clinical application in neurological diseases in the future. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Practitioners (doctors, other healthcare professionals) | 1 | 33% |
Science communicators (journalists, bloggers, editors) | 1 | 33% |
Members of the public | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 2 | 3% |
Austria | 1 | 1% |
Netherlands | 1 | 1% |
Belgium | 1 | 1% |
Spain | 1 | 1% |
Unknown | 74 | 93% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 21 | 26% |
Student > Ph. D. Student | 14 | 18% |
Student > Master | 9 | 11% |
Student > Bachelor | 7 | 9% |
Student > Doctoral Student | 5 | 6% |
Other | 9 | 11% |
Unknown | 15 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 23 | 29% |
Agricultural and Biological Sciences | 16 | 20% |
Biochemistry, Genetics and Molecular Biology | 7 | 9% |
Engineering | 7 | 9% |
Medicine and Dentistry | 5 | 6% |
Other | 6 | 8% |
Unknown | 16 | 20% |