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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Transvenous vagus nerve stimulation does not modulate the innate immune response during experimental human endotoxemia: a randomized controlled study
|
|---|---|
| Published in |
Arthritis Research & Therapy, June 2015
|
| DOI | 10.1186/s13075-015-0667-5 |
| Pubmed ID | |
| Authors |
Matthijs Kox, Lucas T. van Eijk, Tim Verhaak, Tim Frenzel, Harmke D. Kiers, Jelle Gerretsen, Johannes G. van der Hoeven, Lilian Kornet, Avram Scheiner, Peter Pickkers |
| Abstract |
Vagus nerve stimulation (VNS) exerts beneficial anti-inflammatory effects in various animal models of inflammation, including collagen-induced arthritis, and is implicated to represent a novel therapy for rheumatoid arthritis. However, evidence of anti-inflammatory effects of VNS in humans is very scarce. Transvenous VNS (tVNS) is a newly developed and less invasive method to stimulate the vagus nerve. In the present study, we determined whether tVNS is a feasible and safe procedure and investigated its putative anti-inflammatory effects during experimental human endotoxemia. We performed a randomized double-blind sham-controlled study in healthy male volunteers. A stimulation catheter was inserted in the left internal jugular vein at spinal level C5-C7, adjacent to the vagus nerve. In the tVNS group (n=10), stimulation was continuously performed for 30 minutes (0-10 V, 1 ms, 20 Hz), starting 10 minutes before intravenous administration of 2 ng kg(-1) E. Coli LPS. Sham-instrumented subjects (n=10) received no electrical stimulation. No serious adverse events occurred throughout the study. In the tVNS group, stimulation of the vagus nerve was achieved as indicated by laryngeal vibration. Endotoxemia resulted in fever, flu-like symptoms, and hemodynamic changes that were unaffected by tVNS. Furthermore, plasma levels of inflammatory cytokines increased sharply during endotoxemia, but responses were similar between groups. Finally, cytokine production by leukocytes stimulated with LPS ex vivo, as well as neutrophil phagocytosis capacity were not influenced by tVNS. tVNS is feasible and safe, but does not modulate the innate immune response in humans in vivo during experimental human endotoxemia. Clinicaltrials.gov NCT01944228 . Registered 12 September 2013. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 92 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Unknown | 91 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 17% |
| Researcher | 15 | 16% |
| Student > Bachelor | 8 | 9% |
| Student > Master | 6 | 7% |
| Student > Doctoral Student | 4 | 4% |
| Other | 11 | 12% |
| Unknown | 32 | 35% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 27 | 29% |
| Engineering | 7 | 8% |
| Neuroscience | 7 | 8% |
| Biochemistry, Genetics and Molecular Biology | 4 | 4% |
| Nursing and Health Professions | 4 | 4% |
| Other | 11 | 12% |
| Unknown | 32 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 June 2017.
All research outputs
#19,944,091
of 25,373,627 outputs
Outputs from Arthritis Research & Therapy
#2,814
of 3,381 outputs
Outputs of similar age
#192,116
of 280,349 outputs
Outputs of similar age from Arthritis Research & Therapy
#49
of 62 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 18th percentile – i.e., 18% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,381 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one is in the 14th percentile – i.e., 14% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,349 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 62 others from the same source and published within six weeks on either side of this one. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.