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Clinical performance of stem cell therapy in patients with acute-on-chronic liver failure: a systematic review and meta-analysis

Overview of attention for article published in Journal of Translational Medicine, May 2018
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Title
Clinical performance of stem cell therapy in patients with acute-on-chronic liver failure: a systematic review and meta-analysis
Published in
Journal of Translational Medicine, May 2018
DOI 10.1186/s12967-018-1464-0
Pubmed ID
Authors

Ran Xue, Qinghua Meng, Jinling Dong, Juan Li, Qinwei Yao, Yueke Zhu, Hongwei Yu

Abstract

Stem cell therapy has been applied in the treatment of acute-on-chronic liver failure (ACLF). However, its clinical efficiency is still debatable. The aim of this systematic review and meta-analysis is to evaluate the clinical efficiency of stem cell therapy in the treatment of ACLF. The Cochrane Library, OVID, EMBASE, and PUBMED were searched to December 2017. Both randomized and non-randomized studies, assessing stem cell therapy in patients with ACLF, were included. The outcome measures were total bilirubin (TBIL), alanine transaminase (ALT), international normalized ratio (INR), albumin (ALB), and the model for end-stage liver disease (MELD) score. The quality of evidence was assessed by GRADEpro. Four randomized controlled trials and six non-randomized controlled trials were included. The TBIL levels significantly decreased at 1-, 3-, 12-month after the stem cell therapy (p = 0.0008; p = 0.04; p = 0.007). The ALT levels decreased significantly compared with the control group in the short-term (p < 0.00001). There was no obvious change in the INR level compared with the control groups (p = 0.64). The ALB levels increased markedly as compared with the control groups (p < 0.0001). The significant difference can be found in MELD score between stem cell therapy and control groups (p = 0.008). Further subgroup analysis for 3-month clinical performance according to the stem cell types have also been performed. This study suggests that the clinical outcomes of stem cell therapy were satisfied in patients with ACLF in the short-term. MSCs may be better than BM-MNCs in the stem cells transplantation of ACLF. However, more attention should focus on clinical trials in large-volume centers.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 31 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 5 16%
Student > Master 4 13%
Researcher 3 10%
Student > Ph. D. Student 3 10%
Student > Doctoral Student 2 6%
Other 7 23%
Unknown 7 23%
Readers by discipline Count As %
Medicine and Dentistry 15 48%
Nursing and Health Professions 4 13%
Biochemistry, Genetics and Molecular Biology 3 10%
Environmental Science 1 3%
Materials Science 1 3%
Other 0 0%
Unknown 7 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 May 2018.
All research outputs
#11,488,844
of 12,926,183 outputs
Outputs from Journal of Translational Medicine
#2,401
of 2,557 outputs
Outputs of similar age
#234,130
of 270,138 outputs
Outputs of similar age from Journal of Translational Medicine
#1
of 1 outputs
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