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GABAergic inhibition is weakened or converted into excitation in the oxytocin and vasopressin neurons of the lactating rat

Overview of attention for article published in Molecular Brain, May 2015
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Title
GABAergic inhibition is weakened or converted into excitation in the oxytocin and vasopressin neurons of the lactating rat
Published in
Molecular Brain, May 2015
DOI 10.1186/s13041-015-0123-0
Pubmed ID
Authors

Seung Won Lee, Young-Beom Kim, Jeong Sook Kim, Woong Bin Kim, Yoon Sik Kim, Hee Chul Han, Christopher S. Colwell, Young-Wuk Cho, Yang In Kim

Abstract

Increased secretion of oxytocin and arginine vasopressin (AVP) from hypothalamic magnocellular neurosecretory cells (MNCs) is a key physiological response to lactation. In the current study, we sought to test the hypothesis that the GABAA receptor-mediated inhibition of MNCs is altered in lactating rats. Gramicidin-perforated recordings in the rat supraoptic nucleus (SON) slices revealed that the reversal potential of GABAA receptor-mediated response (EGABA) of MNCs was significantly depolarized in the lactating rats as compared to virgin animals. The depolarizing EGABA shift was much larger in rats in third, than first, lactation such that GABA exerted an excitatory, instead of inhibitory, effect in most of the MNCs of these multiparous rats. Immunohistochemical analyses confirmed that GABAergic excitation was found in both AVP and oxytocin neurons within the MNC population. Pharmacological experiments indicated that the up-regulation of the Cl(-) importer Na(+)-K(+)-2Cl(-) cotransporter isotype 1 and the down-regulation of the Cl(-) extruder K(+)-Cl(-) cotransporter isotype 2 were responsible for the depolarizing shift of EGABA and the resultant emergence of GABAergic excitation in the MNCs of the multiparous rats. We conclude that, in primiparous rats, the GABAergic inhibition of MNCs is weakened during the period of lactation while, in multiparous females, GABA becomes excitatory in a majority of the cells. This reproductive experience-dependent alteration of GABAergic transmission may help to increase the secretion of oxytocin and AVP during the period of lactation.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 40 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 1 3%
Unknown 39 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 23%
Researcher 7 18%
Professor 6 15%
Student > Bachelor 2 5%
Student > Doctoral Student 2 5%
Other 8 20%
Unknown 6 15%
Readers by discipline Count As %
Neuroscience 14 35%
Agricultural and Biological Sciences 10 25%
Biochemistry, Genetics and Molecular Biology 3 8%
Unspecified 1 3%
Physics and Astronomy 1 3%
Other 3 8%
Unknown 8 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 June 2015.
All research outputs
#10,214,134
of 12,786,839 outputs
Outputs from Molecular Brain
#447
of 573 outputs
Outputs of similar age
#160,097
of 233,238 outputs
Outputs of similar age from Molecular Brain
#2
of 3 outputs
Altmetric has tracked 12,786,839 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 573 research outputs from this source. They receive a mean Attention Score of 4.2. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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