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Accelerated extracellular matrix turnover during exacerbations of COPD

Overview of attention for article published in Respiratory Research, June 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (92nd percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Mentioned by

news
1 news outlet
twitter
9 X users
patent
3 patents
facebook
1 Facebook page
googleplus
1 Google+ user

Citations

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81 Dimensions

Readers on

mendeley
95 Mendeley
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Title
Accelerated extracellular matrix turnover during exacerbations of COPD
Published in
Respiratory Research, June 2015
DOI 10.1186/s12931-015-0225-3
Pubmed ID
Authors

Jannie M. B. Sand, Alan J. Knox, Peter Lange, Shu Sun, Jacob H. Kristensen, Diana J. Leeming, Morten A. Karsdal, Charlotte E. Bolton, Simon R. Johnson

Abstract

Exacerbations of chronic obstructive pulmonary disease (COPD) contribute significantly to disease progression. However, the effect on tissue structure and turnover is not well described. There is an urgent clinical need for biomarkers of disease activity associated with disease progression. Extracellular matrix (ECM) turnover reflects activity in tissues and consequently assessment of ECM turnover may serve as biomarkers of disease activity. We hypothesized that the turnover of lung ECM proteins were altered during exacerbations of COPD. 69 patients with COPD hospitalised for an exacerbation were recruited at admission and returned for a 4 weeks follow-up. Competitive ELISAs measuring circulating protein fragments in serum or plasma assessed the formation and degradation of collagen types III (Pro-C3 and C3M, respectively), IV (P4NP 7S and C4M, respectively), and VI (Pro-C6 and C6M, respectively), and degradation of elastin (ELM7 and EL-NE) and versican (VCANM). Circulating levels of C3M, C4M, C6M, ELM7, and EL-NE were elevated during an exacerbation of COPD as compared to follow-up (all P <0.0001), while VCANM levels were decreased (P <0.0001). Pro-C6 levels were decreased and P4NP 7S levels were elevated during exacerbation (P <0.0001). Pro-C3 levels were unchanged. At time of exacerbation, degradation/formation ratios were increased for collagen types III and VI and decreased for collagen type IV. Exacerbations of COPD resulted in elevated levels of circulating fragments of structural proteins, which may serve as markers of disease activity. This suggests that patients with COPD have accelerated ECM turnover during exacerbations which may be related to disease progression.

X Demographics

X Demographics

The data shown below were collected from the profiles of 9 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 95 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Denmark 3 3%
United States 1 1%
Spain 1 1%
Unknown 90 95%

Demographic breakdown

Readers by professional status Count As %
Student > Master 20 21%
Student > Ph. D. Student 20 21%
Researcher 17 18%
Student > Bachelor 9 9%
Other 6 6%
Other 10 11%
Unknown 13 14%
Readers by discipline Count As %
Medicine and Dentistry 18 19%
Agricultural and Biological Sciences 16 17%
Biochemistry, Genetics and Molecular Biology 15 16%
Engineering 7 7%
Pharmacology, Toxicology and Pharmaceutical Science 5 5%
Other 16 17%
Unknown 18 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 21. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 May 2021.
All research outputs
#1,792,818
of 25,371,288 outputs
Outputs from Respiratory Research
#155
of 3,062 outputs
Outputs of similar age
#22,288
of 280,832 outputs
Outputs of similar age from Respiratory Research
#1
of 36 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,062 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.9. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 280,832 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 92% of its contemporaries.
We're also able to compare this research output to 36 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.