Title |
Hypothalamic FTO is associated with the regulation of energy intake not feeding reward
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Published in |
BMC Neuroscience, October 2009
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DOI | 10.1186/1471-2202-10-129 |
Pubmed ID | |
Authors |
Pawel K Olszewski, Robert Fredriksson, Agnieszka M Olszewska, Olga Stephansson, Johan Alsiö, Katarzyna J Radomska, Allen S Levine, Helgi B Schiöth |
Abstract |
Polymorphism in the FTO gene is strongly associated with obesity, but little is known about the molecular bases of this relationship. We investigated whether hypothalamic FTO is involved in energy-dependent overconsumption of food. We determined FTO mRNA levels in rodent models of short- and long-term intake of palatable fat or sugar, deprivation, diet-induced increase in body weight, baseline preference for fat versus sugar as well as in same-weight animals differing in the inherent propensity to eat calories especially upon availability of diverse diets, using quantitative PCR. FTO gene expression was also studied in organotypic hypothalamic cultures treated with anorexigenic amino acid, leucine. In situ hybridization (ISH) was utilized to study FTO signal in reward- and hunger-related sites, colocalization with anorexigenic oxytocin, and c-Fos immunoreactivity in FTO cells at initiation and termination of a meal. |
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Geographical breakdown
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United States | 2 | 2% |
Chile | 1 | <1% |
Netherlands | 1 | <1% |
Iceland | 1 | <1% |
United Kingdom | 1 | <1% |
Unknown | 97 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 22 | 21% |
Researcher | 16 | 16% |
Student > Master | 16 | 16% |
Student > Bachelor | 13 | 13% |
Professor | 5 | 5% |
Other | 15 | 15% |
Unknown | 16 | 16% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 20 | 19% |
Biochemistry, Genetics and Molecular Biology | 17 | 17% |
Neuroscience | 7 | 7% |
Psychology | 6 | 6% |
Other | 8 | 8% |
Unknown | 21 | 20% |