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Hypothalamic FTO is associated with the regulation of energy intake not feeding reward

Overview of attention for article published in BMC Neuroscience, October 2009
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (86th percentile)
  • High Attention Score compared to outputs of the same age and source (91st percentile)

Mentioned by

blogs
1 blog

Citations

dimensions_citation
95 Dimensions

Readers on

mendeley
91 Mendeley
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Title
Hypothalamic FTO is associated with the regulation of energy intake not feeding reward
Published in
BMC Neuroscience, October 2009
DOI 10.1186/1471-2202-10-129
Pubmed ID
Authors

Pawel K Olszewski, Robert Fredriksson, Agnieszka M Olszewska, Olga Stephansson, Johan Alsiö, Katarzyna J Radomska, Allen S Levine, Helgi B Schiöth

Abstract

Polymorphism in the FTO gene is strongly associated with obesity, but little is known about the molecular bases of this relationship. We investigated whether hypothalamic FTO is involved in energy-dependent overconsumption of food. We determined FTO mRNA levels in rodent models of short- and long-term intake of palatable fat or sugar, deprivation, diet-induced increase in body weight, baseline preference for fat versus sugar as well as in same-weight animals differing in the inherent propensity to eat calories especially upon availability of diverse diets, using quantitative PCR. FTO gene expression was also studied in organotypic hypothalamic cultures treated with anorexigenic amino acid, leucine. In situ hybridization (ISH) was utilized to study FTO signal in reward- and hunger-related sites, colocalization with anorexigenic oxytocin, and c-Fos immunoreactivity in FTO cells at initiation and termination of a meal.

Mendeley readers

The data shown below were compiled from readership statistics for 91 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 2%
United Kingdom 1 1%
Chile 1 1%
Iceland 1 1%
Netherlands 1 1%
Unknown 85 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 22 24%
Researcher 16 18%
Student > Master 15 16%
Student > Bachelor 11 12%
Professor 5 5%
Other 15 16%
Unknown 7 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 24 26%
Medicine and Dentistry 18 20%
Biochemistry, Genetics and Molecular Biology 17 19%
Neuroscience 7 8%
Psychology 6 7%
Other 6 7%
Unknown 13 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 May 2010.
All research outputs
#631,519
of 4,035,698 outputs
Outputs from BMC Neuroscience
#79
of 597 outputs
Outputs of similar age
#9,181
of 67,926 outputs
Outputs of similar age from BMC Neuroscience
#1
of 12 outputs
Altmetric has tracked 4,035,698 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 597 research outputs from this source. They receive a mean Attention Score of 3.0. This one has done well, scoring higher than 86% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 67,926 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.