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Transcriptome display during tilapia sex determination and differentiation as revealed by RNA-Seq analysis

Overview of attention for article published in BMC Genomics, May 2018
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4 tweeters

Citations

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25 Dimensions

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67 Mendeley
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Title
Transcriptome display during tilapia sex determination and differentiation as revealed by RNA-Seq analysis
Published in
BMC Genomics, May 2018
DOI 10.1186/s12864-018-4756-0
Pubmed ID
Authors

Wenjing Tao, Jinlin Chen, Dejie Tan, Jing Yang, Lina Sun, Jing Wei, Matthew A. Conte, Thomas D. Kocher, Deshou Wang

Abstract

The factors determining sex in teleosts are diverse. Great efforts have been made to characterize the underlying genetic network in various species. However, only seven master sex-determining genes have been identified in teleosts. While the function of a few genes involved in sex determination and differentiation has been studied, we are far from fully understanding how genes interact to coordinate in this process. To enable systematic insights into fish sexual differentiation, we generated a dynamic co-expression network from tilapia gonadal transcriptomes at 5, 20, 30, 40, 90, and 180 dah (days after hatching), plus 45 and 90 dat (days after treatment) and linked gene expression profiles to both development and sexual differentiation. Transcriptomic profiles of female and male gonads at 5 and 20 dah exhibited high similarities except for a small number of genes that were involved in sex determination, while drastic changes were observed from 90 to 180 dah, with a group of differently expressed genes which were involved in gonadal differentiation and gametogenesis. Weighted gene correlation network analysis identified changes in the expression of Borealin, Gtsf1, tesk1, Zar1, Cdn15, and Rpl that were correlated with the expression of genes previously known to be involved in sex differentiation, such as Foxl2, Cyp19a1a, Gsdf, Dmrt1, and Amh. Global gonadal gene expression kinetics during sex determination and differentiation have been extensively profiled in tilapia. These findings provide insights into the genetic framework underlying sex determination and sexual differentiation, and expand our current understanding of developmental pathways during teleost sex determination.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 67 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 67 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 14 21%
Researcher 11 16%
Student > Master 11 16%
Student > Doctoral Student 7 10%
Other 4 6%
Other 5 7%
Unknown 15 22%
Readers by discipline Count As %
Agricultural and Biological Sciences 23 34%
Biochemistry, Genetics and Molecular Biology 14 21%
Veterinary Science and Veterinary Medicine 2 3%
Unspecified 1 1%
Computer Science 1 1%
Other 1 1%
Unknown 25 37%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 December 2018.
All research outputs
#8,093,947
of 14,051,565 outputs
Outputs from BMC Genomics
#4,285
of 8,213 outputs
Outputs of similar age
#141,694
of 274,871 outputs
Outputs of similar age from BMC Genomics
#8
of 21 outputs
Altmetric has tracked 14,051,565 research outputs across all sources so far. This one is in the 40th percentile – i.e., 40% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,213 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 43rd percentile – i.e., 43% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 274,871 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 45th percentile – i.e., 45% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.