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Lipodystrophy among HIV-infected patients: a cross-sectional study on impact on quality of life and mental health disorders

Overview of attention for article published in AIDS Research and Therapy, June 2015
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  • High Attention Score compared to outputs of the same age and source (87th percentile)

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Citations

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Title
Lipodystrophy among HIV-infected patients: a cross-sectional study on impact on quality of life and mental health disorders
Published in
AIDS Research and Therapy, June 2015
DOI 10.1186/s12981-015-0061-z
Pubmed ID
Authors

Charlotte M Verolet, Cécile Delhumeau-Cartier, Marlène Sartori, Simona Toma, Sophie Zawadynski, Minerva Becker, Enos Bernasconi, Laurence Toutous Trellu, Alexandra Calmy, The LIPO Group Metabolism

Abstract

Lipodystrophy (LD) is a frequent adverse event of combination antiretroviral therapy (ART) and occurs mainly in patients exposed to first-generation antiretroviral drugs. The aim of this study was to explore and measure the interaction between LD, mental health, and quality of life of human immunodeficiency virus (HIV) positive individuals seen in a metabolic clinic. We conducted a single-site cross-sectional study including all HIV-infected patients attending the LIPO group and metabolism day clinic at the University Hospitals of Geneva, Switzerland between January 31, 2008 and November 28, 2013. Data on LD were prospectively collected using the HIV Outpatient Study (HOPS) score, the Lipodystrophy Case Definition (LDCD), ART regimens, anthropometric measures, imaging, and standardized questionnaires. Quality of life was evaluated using a visual analog scale of 0-100. Depression and anxiety were assessed using the Beck Depression Inventory and the State Trait Anxiety Inventory scales, respectively. One hundred ninety-four patients (54.6% male; 45.4% female; median age, 50 years) on successful ART (median CD4 cell count, 569.0 cells/mm(3); median viral load, 20 copies/mL) were evaluated. Among these, 62.7, 63.5 and 35.5% of patients reported at least one body site affected by fat hypertrophy, atrophy or both, respectively. Using the LDCD score conservative definition, including imaging and biological values, 57.8% were diagnosed with LD. Of these, 39.7% suffered from severe/very severe LD. Depression was reported by 35.6% of individuals; 51.9% had anxiety symptoms and 49.5% reported poor quality of life (defined as being inferior to 50% on a scale from 0 to 100%). LD (odds ratio (OR = 5.22, 95% confidence interval (CI) 1.07-25.37, p-value: 0.040), depression (OR = 4.67, 95% CI 1.08-20.31, p-value 0.040), and anxiety (OR = 7.83, 95% CI 1.91-32.03, p-value 0.004) all affected significantly the quality of life. LD, depression and anxiety were frequent features among HIV-infected individuals seen in the metabolic clinic and significantly impacted on their quality of life.

X Demographics

X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 64 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Malaysia 1 2%
China 1 2%
Switzerland 1 2%
Unknown 61 95%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 9 14%
Student > Master 9 14%
Student > Doctoral Student 7 11%
Student > Postgraduate 6 9%
Researcher 6 9%
Other 13 20%
Unknown 14 22%
Readers by discipline Count As %
Medicine and Dentistry 19 30%
Psychology 7 11%
Nursing and Health Professions 7 11%
Biochemistry, Genetics and Molecular Biology 3 5%
Immunology and Microbiology 2 3%
Other 8 13%
Unknown 18 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 5. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 October 2018.
All research outputs
#5,913,605
of 22,914,829 outputs
Outputs from AIDS Research and Therapy
#166
of 554 outputs
Outputs of similar age
#67,352
of 264,467 outputs
Outputs of similar age from AIDS Research and Therapy
#2
of 8 outputs
Altmetric has tracked 22,914,829 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 554 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.7. This one has gotten more attention than average, scoring higher than 69% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,467 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 8 others from the same source and published within six weeks on either side of this one. This one has scored higher than 6 of them.