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The within host dynamics of Mycobacterium avium ssp. paratuberculosis infection in cattle: where time and place matter

Overview of attention for article published in Veterinary Research, June 2015
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Title
The within host dynamics of Mycobacterium avium ssp. paratuberculosis infection in cattle: where time and place matter
Published in
Veterinary Research, June 2015
DOI 10.1186/s13567-015-0185-0
Pubmed ID
Authors

Ad P Koets, Shigetoshi Eda, Srinand Sreevatsan

Abstract

Johne's disease or paratuberculosis, caused by Mycobacterium avium subsp. paratuberculosis (MAP), occurs in domestic and wild animals worldwide, causing a significant economic loss to livestock industries. After a prolonged incubation time, infected cattle shed MAP bacilli into feces and spread the disease to an uninfected animal population. It is largely unknown how (or whether) the interplay between the pathogen and the host immunity determines timing of shedding after the long incubation time. Such information would provide an understanding of pathogenesis in individual animals and the epidemiology of MAP infection in animal populations. In this review, we summarize current knowledge of bovine Johne's disease pathology, pathogenesis, immunology and genetics. We discuss knowledge gaps that direly need to be addressed to provide a science-based approach to diagnostics and (immuno)prophylaxis. These knowledge gaps are related to anatomical/clinical manifestation of MAP invasion, interaction of bacteria with phagocytes, granuloma formation, shedding, establishment and kinetics of adaptive immune responses in the pathogenesis of the disease. These topics are discussed at the molecular, cellular and tissue levels with special attention to the within host dynamics including the temporal and the spatial context relevant for the various host-pathogen interactions.

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The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 52 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 17%
Student > Master 8 15%
Researcher 7 13%
Other 5 10%
Student > Doctoral Student 3 6%
Other 6 12%
Unknown 14 27%
Readers by discipline Count As %
Veterinary Science and Veterinary Medicine 18 35%
Agricultural and Biological Sciences 7 13%
Immunology and Microbiology 4 8%
Biochemistry, Genetics and Molecular Biology 3 6%
Medicine and Dentistry 2 4%
Other 1 2%
Unknown 17 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 June 2015.
All research outputs
#17,286,645
of 25,374,917 outputs
Outputs from Veterinary Research
#837
of 1,337 outputs
Outputs of similar age
#166,120
of 278,845 outputs
Outputs of similar age from Veterinary Research
#17
of 33 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,337 research outputs from this source. They receive a mean Attention Score of 5.0. This one is in the 27th percentile – i.e., 27% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 278,845 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.