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A retrospective cohort study of body mass index and survival in HIV infected patients with and without TB co-infection

Overview of attention for article published in Infectious Diseases of Poverty, April 2018
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Title
A retrospective cohort study of body mass index and survival in HIV infected patients with and without TB co-infection
Published in
Infectious Diseases of Poverty, April 2018
DOI 10.1186/s40249-018-0418-3
Pubmed ID
Authors

Kogieleum Naidoo, Nonhlanhla Yende-Zuma, Stanton Augustine

Abstract

High early morbidity and mortality following antiretroviral therapy (ART) initiation has been a distinguishing feature of ART programmes in resource limited settings (RLS) compared to high-income countries. This study assessed how well body mass index (BMI: kg/m2) correlated with survival among HIV infected patients with and without TB co-infection. We retrospectively evaluated clinical data from 1000 HIV infected patients, among whom 389 were also co-infected with TB, between January 2008 and December 2010, in KwaZulu-Natal, South Africa. Among 948 patients eligible for analysis, 15.7% (149/948) were underweight (< 18.50), 55.9% (530/948) had normal BMI (≥18.50-24.90), 18.7% (177/948) were overweight (25.00-29.00) and 9.7% (92/948) were obese (≥30.00). Irrespective of TB status, underweight patients, had significantly higher risk of death compared to those with normal BMI at baseline (aHR = 2.9; 95% CI: 1.5-5.7; P = 0.002). Irrespective of TB co-infection, low BMI correlated with mortality in HIV infected patients. UKZN Biomedical Research Ethics Committee Reference number E 248/05, 23 September 2005.

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Geographical breakdown

Country Count As %
Unknown 85 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 15 18%
Researcher 9 11%
Student > Postgraduate 6 7%
Student > Bachelor 5 6%
Other 4 5%
Other 13 15%
Unknown 33 39%
Readers by discipline Count As %
Medicine and Dentistry 26 31%
Nursing and Health Professions 9 11%
Immunology and Microbiology 5 6%
Unspecified 5 6%
Social Sciences 2 2%
Other 7 8%
Unknown 31 36%