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A delivery system for field application of paratransgenic control

Overview of attention for article published in BMC Biotechnology, June 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#30 of 417)
  • High Attention Score compared to outputs of the same age (86th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (61st percentile)

Mentioned by

news
1 news outlet
twitter
2 tweeters

Citations

dimensions_citation
17 Dimensions

Readers on

mendeley
56 Mendeley
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Title
A delivery system for field application of paratransgenic control
Published in
BMC Biotechnology, June 2015
DOI 10.1186/s12896-015-0175-3
Pubmed ID
Authors

Arinder K. Arora, Adam Forshaw, Thomas A. Miller, Ravi Durvasula

Abstract

As an alternative to chemical pesticides, paratransgenesis relies on transformation of symbiotic bacteria of an arthropod vector to deliver molecules that disrupt pathogen transmission. For over a decade paratransgenesis has remained a laboratory-based endeavor owing to regulatory concerns regarding introduction of transformed microorganisms into the environment. To facilitate field application of paratransgenic strategies, risk mitigation approaches that address environmental contamination and gene spread must be developed. Using biopolymer manipulation, we introduce a novel microencapsulation platform for containment and targeted delivery of engineered bacteria to the gut of a disease-transmitting arthropod. We demonstrate the first proof of principle of targeted delivery of EPA-approved Pantoea agglomerans E325 in a paratransgenic system to control spread of Pierce's Disease by glassy-winged sharpshooters, (Homalodisca vitripennis) under simulated field conditions. Engineered microcapsules may address regulatory concerns regarding containment of recombinant bacteria and environmental spread of foreign genetic material and may represent an important step in translating paratransgenic science beyond the lab and into the field. We present, for the first time, a microencapsulation strategy to deliver recombinant bacteria to an insect and demonstrate targeted release of bacteria into the physiologically relevant region of the insect gut. This is a first step toward addressing concerns related to field application of recombinant bacteria. Engineered microparticles may decrease environmental contamination, horizontal gene transfer and competition with native species by acting as a barrier between recombinant bacteria and the environment.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Switzerland 1 2%
Unknown 54 96%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 11 20%
Student > Ph. D. Student 10 18%
Student > Doctoral Student 5 9%
Researcher 5 9%
Professor 5 9%
Other 14 25%
Unknown 6 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 28 50%
Biochemistry, Genetics and Molecular Biology 11 20%
Chemistry 3 5%
Engineering 2 4%
Social Sciences 2 4%
Other 5 9%
Unknown 5 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 11. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 June 2015.
All research outputs
#470,041
of 5,273,580 outputs
Outputs from BMC Biotechnology
#30
of 417 outputs
Outputs of similar age
#24,287
of 185,495 outputs
Outputs of similar age from BMC Biotechnology
#12
of 39 outputs
Altmetric has tracked 5,273,580 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 417 research outputs from this source. They receive a mean Attention Score of 4.8. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 185,495 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 39 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.