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A cross-sectional study of high-risk human papillomavirus clustering and cervical outcomes in HIV-infected women in Rio de Janeiro, Brazil

Overview of attention for article published in BMC Cancer, June 2015
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (70th percentile)

Mentioned by

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8 tweeters

Citations

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14 Dimensions

Readers on

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63 Mendeley
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Title
A cross-sectional study of high-risk human papillomavirus clustering and cervical outcomes in HIV-infected women in Rio de Janeiro, Brazil
Published in
BMC Cancer, June 2015
DOI 10.1186/s12885-015-1486-4
Pubmed ID
Authors

Jessica L. Castilho, José Eduardo Levi, Paula M. Luz, Mary Catherine Cambou, Tazio Vanni, Angela de Andrade, Mônica Derrico, Valdiléa G. Veloso, Beatriz Grinsztejn, Ruth K. Friedman

Abstract

In Brazil, the rate of cervical cancer remains high despite the availability of screening programs. With ongoing vaccine development and implementation, information on the prevalence of specific HPV types is needed, particularly among high-risk populations, such as HIV-infected women. We performed a study of HIV-infected women in Rio de Janeiro, Brazil, who underwent cervical HPV genotype testing between 2005-2013. We examined the prevalence of high-risk HPV types and the patterns of high-risk HPV type clustering. Using logarithmic binomial regression, we estimated the risk of abnormal cytology by HPV genotype result. Of the 562 women included, 498 (89 %) had at least one HPV type detected. 364 women (65 %) had at least one high-risk HPV type detected and 181 (32 %) had more than one high-risk type detected. HPV 58 was the most frequent HPV type detected overall (prevalence 19.8 % [95 % confidence interval 16.4-23.1]), followed by HPV 53 (prevalence 15.5 % [12.5-18.5]) and HPV 16 (prevalence 13 % [10.2-15.8]). Women infected with more than one high-risk HPV type were younger, had lower CD4+ lymphocyte counts, and were more likely to be infected with HPV 16 or 18. In adjusted analyses, presence of more than one high-risk HPV type was associated with a two-fold increased risk of abnormal cytology after adjusting for presence of individual high-risk type, age, and CD4+ lymphocyte count (adjusted prevalence ratios 1.88-2.07, all p <0.001). No single high-risk HPV type was statistically associated with abnormal cytology after adjusting for the presence of more than one high-risk HPV type. In the largest study of cervical HPV genotypes among HIV-infected women in Latin America, infection by high-risk HPV types other than 16 or 18 and infection by more than one high-risk HPV types were common. Infection by more than one high-risk type was more strongly associated with abnormal cervical cytology than any individual high-risk HPV type, highlighting the need for multi-valent HPV vaccines.

Twitter Demographics

The data shown below were collected from the profiles of 8 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 2 3%
Unknown 61 97%

Demographic breakdown

Readers by professional status Count As %
Student > Master 14 22%
Researcher 7 11%
Student > Bachelor 7 11%
Other 5 8%
Student > Ph. D. Student 4 6%
Other 11 17%
Unknown 15 24%
Readers by discipline Count As %
Medicine and Dentistry 21 33%
Nursing and Health Professions 7 11%
Immunology and Microbiology 4 6%
Social Sciences 3 5%
Biochemistry, Genetics and Molecular Biology 2 3%
Other 8 13%
Unknown 18 29%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 April 2016.
All research outputs
#4,520,455
of 15,449,825 outputs
Outputs from BMC Cancer
#1,187
of 5,792 outputs
Outputs of similar age
#67,368
of 233,765 outputs
Outputs of similar age from BMC Cancer
#1
of 1 outputs
Altmetric has tracked 15,449,825 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 5,792 research outputs from this source. They receive a mean Attention Score of 4.1. This one has done well, scoring higher than 78% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 233,765 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 70% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them