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Different tenogenic differentiation capacities of different mesenchymal stem cells in the presence of BMP-12

Overview of attention for article published in Journal of Translational Medicine, June 2015
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2 tweeters

Citations

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46 Dimensions

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66 Mendeley
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Title
Different tenogenic differentiation capacities of different mesenchymal stem cells in the presence of BMP-12
Published in
Journal of Translational Medicine, June 2015
DOI 10.1186/s12967-015-0560-7
Pubmed ID
Authors

Linghui Dai, Xiaoqing Hu, Xin Zhang, Jingxian Zhu, Jiying Zhang, Xin Fu, Xiaoning Duan, Yingfang Ao, Chunyan Zhou

Abstract

Mesenchymal stem cells (MSCs) are regarded as a promising cell-based therapeutic tool for tendon repair. This study aimed to compare the different tenogenic differentiation capacities of the three types of MSCs in the presence of bone morphogenic protein 12 (BMP-12). MSCs were isolated from rat bone marrow (BM), inguinal adipose tissue (AD), and synovium (SM) from the knee joint. MSCs were characterized by morphology, proliferation, trilineage differentiation, and surface marker analysis. Tenogenic differentiation potential was initially assessed using real-time polymerase chain reaction, Western blot, and enzyme-linked immunosorbent assay in vitro. Histological assessments were also performed after subcutaneous implantation of BMP-12 recombinant adenovirus-infected MSCs in nude mice in vivo. The three types of MSCs exhibited similar fibroblast-like morphology and surface markers but different differentiation potentials toward adipogenic, osteogenic, and chondrogenic lineage fates. Bone marrow-derived MSCs (BM-MSCs) showed the most superior in vitro tenogenic differentiation capacity, followed by synovial membrane-derived MSCs (SM-MSCs) and then adipose-derived MSCs (AD-MSCs). After implantation, all three types of MSC masses infected with BMP-12 recombinant adenovirus emerged in the form of fiber-like matrix, especially in 6-week specimens, compared with the control MSCs in vivo. BM-MSCs and SM-MSCs revealed more intense staining for collagen type I (Col I) compared with AD-MSCs. Differences were not observed between BM-MSCs and SM-MSCs. However, SM-MSCs demonstrated higher proliferation capacity than BM-MSCs. BM-MSCs exhibited the most superior tenogenic differentiation capacity, followed by SM-MSCs. By contrast, AD-MSCs demonstrated the inferior capacity among the three types of MSCs in the presence of BMP-12 both in vivo and in vitro.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 66 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 2%
United States 1 2%
Unknown 64 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 14 21%
Student > Master 11 17%
Researcher 10 15%
Student > Bachelor 8 12%
Student > Doctoral Student 7 11%
Other 6 9%
Unknown 10 15%
Readers by discipline Count As %
Medicine and Dentistry 22 33%
Biochemistry, Genetics and Molecular Biology 8 12%
Engineering 7 11%
Agricultural and Biological Sciences 7 11%
Nursing and Health Professions 2 3%
Other 8 12%
Unknown 12 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 July 2015.
All research outputs
#2,450,573
of 5,310,151 outputs
Outputs from Journal of Translational Medicine
#559
of 1,496 outputs
Outputs of similar age
#85,664
of 186,680 outputs
Outputs of similar age from Journal of Translational Medicine
#52
of 98 outputs
Altmetric has tracked 5,310,151 research outputs across all sources so far. This one has received more attention than most of these and is in the 51st percentile.
So far Altmetric has tracked 1,496 research outputs from this source. They receive a mean Attention Score of 4.2. This one has gotten more attention than average, scoring higher than 54% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 186,680 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 50% of its contemporaries.
We're also able to compare this research output to 98 others from the same source and published within six weeks on either side of this one. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.