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BEWARE: Body awareness training in the treatment of wearing-off related anxiety in patients with Parkinson’s disease: study protocol for a randomized controlled trial

Overview of attention for article published in Trials, June 2015
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Title
BEWARE: Body awareness training in the treatment of wearing-off related anxiety in patients with Parkinson’s disease: study protocol for a randomized controlled trial
Published in
Trials, June 2015
DOI 10.1186/s13063-015-0804-0
Pubmed ID
Authors

Ires Ghielen, Odile A. van den Heuvel, Cees J. T. de Goede, Marieke Houniet-de Gier, Emma H. Collette, Ingrid A. L. Burgers-Bots, Sonja Rutten, Gert Kwakkel, Kees Vermunt, Bep van Vliet, Henk W. Berendse, Erwin E. H. van Wegen

Abstract

The wearing-off phenomenon in patients with Parkinson's disease (PD) is a complication of prolonged levodopa usage. During this phenomenon, motor symptoms such as rigidity and freezing re-emerge. This is often accompanied by non-motor symptoms, including anxiety, the so-called wearing-off related anxiety (WRA). Current treatment options are limited and typically focus on either the physical or mental aspects of wearing-off. An integrated approach seems warranted in order to optimally address the complex reciprocal interactions between these aspects. Also, because wearing-off is eventually inescapable, treatment needs to focus on coping, acceptance, and self-efficacy. We therefore developed an integrated body awareness intervention, combining principles from physical therapy with acceptance and commitment therapy to teach patients to deal with WRA. This study will investigate whether this new intervention, named BEWARE, is more effective than treatment as usual in increasing self-efficacy. This is a single-blinded randomized controlled trial in 36 PD patients who experience WRA. Subjects will be recruited from the outpatient clinic for movement disorders of the VU University Medical Center. After providing written informed consent, patients will be randomly assigned to an experimental (BEWARE) or treatment-as-usual (physical therapy) group. Clinical assessments will be performed prior to the intervention, directly after the 6-week intervention period, and at 3-month naturalistic follow-up by a blinded investigator not involved in the study. The primary outcome measure is self-efficacy, and secondary outcomes focus on mobility, daily functioning, anxiety, and quality of life. Because wearing-off is an inevitable consequence of levodopa therapy and current treatment options are insufficient, a multidisciplinary intervention that addresses both physical and mental aspects of wearing-off in PD may foster additional benefits for treating WRA in PD patients over mono-disciplinary care alone. ClinicalTrials.gov identifier: NCT02054845 . Date of registration: 30 January 2014.

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Mendeley readers

The data shown below were compiled from readership statistics for 171 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 1 <1%
Unknown 170 99%

Demographic breakdown

Readers by professional status Count As %
Student > Master 22 13%
Student > Bachelor 22 13%
Student > Ph. D. Student 19 11%
Researcher 18 11%
Student > Doctoral Student 13 8%
Other 34 20%
Unknown 43 25%
Readers by discipline Count As %
Medicine and Dentistry 35 20%
Psychology 32 19%
Nursing and Health Professions 28 16%
Neuroscience 12 7%
Sports and Recreations 5 3%
Other 13 8%
Unknown 46 27%