Title |
Inferring pathway dysregulation in cancers from multiple types of omic data
|
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Published in |
Genome Medicine, June 2015
|
DOI | 10.1186/s13073-015-0189-4 |
Pubmed ID | |
Authors |
Shelley M MacNeil, William E Johnson, Dean Y Li, Stephen R Piccolo, Andrea H Bild |
Abstract |
Although in some cases individual genomic aberrations may drive disease development in isolation, a complex interplay among multiple aberrations is common. Accordingly, we developed Gene Set Omic Analysis (GSOA), a bioinformatics tool that can evaluate multiple types and combinations of omic data at the pathway level. GSOA uses machine learning to identify dysregulated pathways and improves upon other methods because of its ability to decipher complex, multigene patterns. We compare GSOA to alternative methods and demonstrate its ability to identify pathways known to play a role in various cancer phenotypes. Software implementing the GSOA method is freely available from https://bitbucket.org/srp33/gsoa. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 6 | 46% |
United Kingdom | 2 | 15% |
Canada | 1 | 8% |
Unknown | 4 | 31% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 10 | 77% |
Members of the public | 2 | 15% |
Practitioners (doctors, other healthcare professionals) | 1 | 8% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Germany | 1 | 1% |
France | 1 | 1% |
Belgium | 1 | 1% |
Unknown | 64 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 22 | 33% |
Researcher | 19 | 28% |
Student > Master | 5 | 7% |
Student > Bachelor | 5 | 7% |
Student > Doctoral Student | 3 | 4% |
Other | 7 | 10% |
Unknown | 6 | 9% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 21 | 31% |
Biochemistry, Genetics and Molecular Biology | 17 | 25% |
Computer Science | 11 | 16% |
Medicine and Dentistry | 5 | 7% |
Unspecified | 1 | 1% |
Other | 3 | 4% |
Unknown | 9 | 13% |