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The impact of an exercise intervention on C - reactive protein during pregnancy: a randomized controlled trial

Overview of attention for article published in BMC Pregnancy and Childbirth, June 2015
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Title
The impact of an exercise intervention on C - reactive protein during pregnancy: a randomized controlled trial
Published in
BMC Pregnancy and Childbirth, June 2015
DOI 10.1186/s12884-015-0576-2
Pubmed ID
Authors

Marquis Hawkins, Barry Braun, Bess H. Marcus, Edward Stanek, Glenn Markenson, Lisa Chasan-Taber

Abstract

C-reactive protein (CRP) during pregnancy has been associated with adverse maternal outcomes such as preeclampsia and gestational diabetes mellitus. Randomized trials suggest that exercise programs may be associated with reductions in CRP in non-pregnant populations; however, such studies have not been conducted among pregnant women. The purpose of this study was to evaluate the impact of an individually-tailored motivationally-matched exercise intervention on CRP in pregnant women. The Behaviors Affecting Baby and You study was a randomized controlled trial of prenatal physical activity to prevent the development of gestational diabetes mellitus in women at increased risk. Women were randomized to either a 12-week exercise intervention (n = 84) or a comparison health and wellness intervention (n = 87). High sensitivity CRP (mg/dL) was measured using a commercial immunoassay kit. Physical activity was measured using the Pregnancy Physical Activity Questionnaire. Mixed model analyses were used to evaluate the impact of the intervention on change in CRP using an intent-to-treat approach. CRP decreased (-0.09 mg/dL, 95 % CI: -0.25, 0.07) from pre- to post-intervention in the exercise arm (p = 0.14) and increased (0.08 mg/dL, 95 % CI: -0.07, 0.24) (p = 0.64) in the health and wellness arm; however the between group difference was not statistically significant (p = 0.14). Findings did not differ according to ethnic group or pre-pregnancy body mass index. In a secondary analysis based on self-reported physical activity, women who decreased their time spent in sports/exercise experienced a mean increase in CRP (0.09 mg/dL, 95 % CI: -0.14, 0.33), whereas women who maintained or increased their sports/ exercise experienced a mean decrease in CRP (-0.08 mg/dL, 95 % CI: -0.23, 0.08) (p = 0.046). Findings from this randomized trial in an ethnically and socio-economically diverse population of pregnant women were consistent with a positive impact of the exercise intervention on CRP levels, but not of statistical significance. ClinicalTrials.gov: NCT00728377 . Registered 2 August 2008.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 214 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 214 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 37 17%
Student > Bachelor 34 16%
Student > Ph. D. Student 15 7%
Student > Doctoral Student 15 7%
Student > Postgraduate 13 6%
Other 30 14%
Unknown 70 33%
Readers by discipline Count As %
Medicine and Dentistry 41 19%
Nursing and Health Professions 36 17%
Sports and Recreations 22 10%
Psychology 10 5%
Agricultural and Biological Sciences 6 3%
Other 21 10%
Unknown 78 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 June 2015.
All research outputs
#18,417,643
of 22,815,414 outputs
Outputs from BMC Pregnancy and Childbirth
#3,471
of 4,191 outputs
Outputs of similar age
#189,618
of 264,049 outputs
Outputs of similar age from BMC Pregnancy and Childbirth
#43
of 50 outputs
Altmetric has tracked 22,815,414 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,191 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one is in the 9th percentile – i.e., 9% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 264,049 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 50 others from the same source and published within six weeks on either side of this one. This one is in the 6th percentile – i.e., 6% of its contemporaries scored the same or lower than it.