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Modulation of interleukin-1β-induced inflammatory responses by a synthetic cationic innate defence regulator peptide, IDR-1002, in synovial fibroblasts

Overview of attention for article published in Arthritis Research & Therapy, August 2011
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Mentioned by

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2 patents

Citations

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41 Dimensions

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43 Mendeley
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Title
Modulation of interleukin-1β-induced inflammatory responses by a synthetic cationic innate defence regulator peptide, IDR-1002, in synovial fibroblasts
Published in
Arthritis Research & Therapy, August 2011
DOI 10.1186/ar3440
Pubmed ID
Authors

Emily Turner-Brannen, Ka-Yee Choi, Dustin ND Lippert, John P Cortens, Robert EW Hancock, Hani El-Gabalawy, Neeloffer Mookherjee

Abstract

Innate defence regulator (IDR) peptides are synthetic cationic peptides, variants of naturally occurring innate immune effector molecules known as host defence peptides. IDR peptides were recently demonstrated to limit infection-associated inflammation selectively without compromising host innate immune functions. This study examined the impact of a 12-amino acid IDR peptide, IDR-1002, in pro-inflammatory cytokine interleukin (IL)-1β-induced responses in synovial fibroblasts, a critical cell type in the pathogenesis of inflammatory arthritis.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Netherlands 1 2%
Unknown 41 95%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 30%
Student > Master 8 19%
Researcher 7 16%
Student > Doctoral Student 2 5%
Student > Bachelor 2 5%
Other 8 19%
Unknown 3 7%
Readers by discipline Count As %
Medicine and Dentistry 11 26%
Agricultural and Biological Sciences 9 21%
Biochemistry, Genetics and Molecular Biology 6 14%
Immunology and Microbiology 5 12%
Unspecified 1 2%
Other 7 16%
Unknown 4 9%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 December 2013.
All research outputs
#8,534,976
of 25,373,627 outputs
Outputs from Arthritis Research & Therapy
#1,710
of 3,381 outputs
Outputs of similar age
#47,047
of 131,748 outputs
Outputs of similar age from Arthritis Research & Therapy
#21
of 41 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,381 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one is in the 38th percentile – i.e., 38% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 131,748 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 36th percentile – i.e., 36% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 41 others from the same source and published within six weeks on either side of this one. This one is in the 19th percentile – i.e., 19% of its contemporaries scored the same or lower than it.