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Core oxidative stress response in Aspergillus nidulans

Overview of attention for article published in BMC Genomics, June 2015
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Title
Core oxidative stress response in Aspergillus nidulans
Published in
BMC Genomics, June 2015
DOI 10.1186/s12864-015-1705-z
Pubmed ID
Authors

Tamás Emri, Vera Szarvas, Erzsébet Orosz, Károly Antal, HeeSoo Park, Kap-Hoon Han, Jae-Hyuk Yu, István Pócsi

Abstract

The b-Zip transcription factor AtfA plays a key role in regulating stress responses in the filamentous fungus Aspergillus nidulans. To identify the core regulons of AtfA, we examined genome-wide expression changes caused by various stresses in the presence/absence of AtfA using A. nidulans microarrays. We also intended to address the intriguing question regarding the existence of core environmental stress response in this important model eukaryote. Examination of the genome wide expression changes caused by five different oxidative stress conditions in wild type and the atfA null mutant has identified a significant number of stereotypically regulated genes (Core Oxidative Stress Response genes). The deletion of atfA increased the oxidative stress sensitivity of A. nidulans and affected mRNA accumulation of several genes under both unstressed and stressed conditions. The numbers of genes under the AtfA control appear to be specific to a stress-type. We also found that both oxidative and salt stresses induced expression of some secondary metabolite gene clusters and the deletion of atfA enhanced the stress responsiveness of additional clusters. Moreover, certain clusters were down-regulated by the stresses tested. Our data suggest that the observed co-regulations were most likely consequences of the overlapping physiological effects of the stressors and not of the existence of a general environmental stress response. The function of AtfA in governing various stress responses is much smaller than anticipated and/or other regulators may play a redundant or overlapping role with AtfA. Both stress inducible and stress repressive regulations of secondary metabolism seem to be frequent features in A. nidulans.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 74 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 19 26%
Student > Bachelor 11 15%
Researcher 10 14%
Student > Doctoral Student 8 11%
Student > Master 7 9%
Other 6 8%
Unknown 13 18%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 27 36%
Agricultural and Biological Sciences 25 34%
Immunology and Microbiology 2 3%
Nursing and Health Professions 1 1%
Medicine and Dentistry 1 1%
Other 1 1%
Unknown 17 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 June 2015.
All research outputs
#4,401,753
of 5,285,691 outputs
Outputs from BMC Genomics
#4,244
of 4,751 outputs
Outputs of similar age
#150,455
of 186,440 outputs
Outputs of similar age from BMC Genomics
#222
of 237 outputs
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So far Altmetric has tracked 4,751 research outputs from this source. They receive a mean Attention Score of 3.8. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 237 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.