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PIpelle Prospective ENDOmetrial carcinoma (PIPENDO) study, pre-operative recognition of high risk endometrial carcinoma: a multicentre prospective cohort study

Overview of attention for article published in BMC Cancer, June 2015
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  • Above-average Attention Score compared to outputs of the same age (51st percentile)
  • Above-average Attention Score compared to outputs of the same age and source (59th percentile)

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4 X users

Citations

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18 Dimensions

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59 Mendeley
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Title
PIpelle Prospective ENDOmetrial carcinoma (PIPENDO) study, pre-operative recognition of high risk endometrial carcinoma: a multicentre prospective cohort study
Published in
BMC Cancer, June 2015
DOI 10.1186/s12885-015-1487-3
Pubmed ID
Authors

Nicole C. M. Visser, Johan Bulten, Anneke A. M. van der Wurff, Erik A. Boss, Carolien M. Bronkhorst, Harrie W. H. Feijen, Joke E. Haartsen, Hilde A. D. M. van Herk, Ineke M. de Kievit, Paul J. J. M. Klinkhamer, Brenda M. Pijlman, Marc P. M. L. Snijders, Ingrid Vandenput, M. Caroline Vos, Peter E. J. de Wit, Lonneke V. van de Poll-Franse, Leon F.A.G. Massuger, Johanna M. A. Pijnenborg

Abstract

Endometrial carcinoma is the most common gynaecologic malignancy in industrialised countries and the incidence is still rising. Primary treatment is based on preoperative risk classification and consists in most cases of hysterectomy with bilateral salpingo-oophorectomy. In patients with serous and clear cell histology a complete surgical staging is mandatory. However, in routine clinical practice final histology regularly does not correspond with the preoperative histological diagnosis. This results in both over and under treatment. The aim of this multicentre, prospective cohort study is to select a panel of prognostic biomarkers to improve preoperative diagnosis of endometrial carcinoma in order to identify those patients that need extended surgery and/or additional treatment. Additionally, we will determine whether incorporation of cervical cytology and comorbidity could improve this preoperative risk classification. All patients treated for endometrial carcinoma in the participating hospitals from September 2011 till December 2013 are included. Patient characteristics, as well as comorbidity are registered. Patients without preoperative histology, history of hysterectomy and/or endometrial carcinoma or no surgical treatment including hysterectomy are excluded. The preoperative histology and final pathology will be reviewed and compared by expert pathologists. Additional immunohistochemical analysis of IMP3, p53, ER, PR, MLH1, PTEN, beta-catenin, p16, Ki-67, stathmin, ARID1A and L1CAM will be performed. Preoperative histology will be compared with the final pathology results. Follow-up will be at least 24 months to determine risk factors for recurrence and outcome. This study is designed to improve surgical treatment of endometrial carcinoma patients. A total of 432 endometrial carcinoma patients were enrolled between 2011 and 2013. Follow-up will be completed in 2015. Preoperative histology will be evaluated systematically and background endometrium will be classified. This is the first study incorporating immunohistochemistry, cervical cytology and comorbidity to define the optimal panel of prognostic biomarkers that contribute in clinical decision making in the management of endometrial carcinoma. Netherlands Trial Register number NTR3503.

X Demographics

X Demographics

The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Argentina 1 2%
Brazil 1 2%
Unknown 57 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 14 24%
Student > Master 8 14%
Researcher 6 10%
Student > Bachelor 4 7%
Student > Postgraduate 4 7%
Other 6 10%
Unknown 17 29%
Readers by discipline Count As %
Medicine and Dentistry 21 36%
Nursing and Health Professions 4 7%
Agricultural and Biological Sciences 4 7%
Computer Science 2 3%
Biochemistry, Genetics and Molecular Biology 2 3%
Other 5 8%
Unknown 21 36%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 July 2015.
All research outputs
#13,440,839
of 22,815,414 outputs
Outputs from BMC Cancer
#2,974
of 8,300 outputs
Outputs of similar age
#123,671
of 262,924 outputs
Outputs of similar age from BMC Cancer
#55
of 162 outputs
Altmetric has tracked 22,815,414 research outputs across all sources so far. This one is in the 39th percentile – i.e., 39% of other outputs scored the same or lower than it.
So far Altmetric has tracked 8,300 research outputs from this source. They receive a mean Attention Score of 4.3. This one has gotten more attention than average, scoring higher than 62% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 262,924 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.
We're also able to compare this research output to 162 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.