Title |
Anti-Neuroinflammatory effects of the extract of Achillea fragrantissima
|
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Published in |
BMC Complementary Medicine and Therapies, October 2011
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DOI | 10.1186/1472-6882-11-98 |
Pubmed ID | |
Authors |
Anat Elmann, Sharon Mordechay, Hilla Erlank, Alona Telerman, Miriam Rindner, Rivka Ofir |
Abstract |
The neuroinflammatory process plays a central role in the initiation and progression of neurodegenerative diseases such as Parkinson's and Alzheimer's diseases, and involves the activation of brain microglial cells. During the neuroinflammatory process, microglial cells release proinflammatory mediators such as cytokines, matrix metalloproteinases (MMP), Reactive oxygen species (ROS) and nitric oxide (NO). In the present study, extracts from 66 different desert plants were tested for their effect on lipopolysaccharide (LPS) - induced production of NO by primary microglial cells. The extract of Achillea fragrantissima (Af), which is a desert plant that has been used for many years in traditional medicine for the treatment of various diseases, was the most efficient extract, and was further studied for additional anti-neuroinflammatory effects in these cells. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
India | 2 | 18% |
United States | 1 | 9% |
China | 1 | 9% |
Japan | 1 | 9% |
Unknown | 6 | 55% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 11 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 2% |
Unknown | 60 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 11 | 18% |
Student > Master | 10 | 16% |
Student > Doctoral Student | 6 | 10% |
Researcher | 6 | 10% |
Lecturer | 3 | 5% |
Other | 10 | 16% |
Unknown | 15 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 12 | 20% |
Medicine and Dentistry | 7 | 11% |
Biochemistry, Genetics and Molecular Biology | 5 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 4 | 7% |
Immunology and Microbiology | 2 | 3% |
Other | 12 | 20% |
Unknown | 19 | 31% |