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Estimates of genomic heritability and genome-wide association study for fatty acids profile in Santa Inês sheep

Overview of attention for article published in BMC Genomics, May 2018
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Title
Estimates of genomic heritability and genome-wide association study for fatty acids profile in Santa Inês sheep
Published in
BMC Genomics, May 2018
DOI 10.1186/s12864-018-4777-8
Pubmed ID
Authors

G. A. Rovadoscki, S. F. N. Pertile, A. B. Alvarenga, A. S. M. Cesar, F. Pértille, J. Petrini, V. Franzo, W. V. B. Soares, G. Morota, M. L. Spangler, L. F. B. Pinto, G. G. P. Carvalho, D. P. D. Lanna, L. L. Coutinho, G. B. Mourão

Abstract

Despite the health concerns and nutritional importance of fatty acids, there is a relative paucity of studies in the literature that report genetic or genomic parameters, especially in the case of sheep populations. To investigate the genetic architecture of fatty acid composition of sheep, we conducted genome-wide association studies (GWAS) and estimated genomic heritabilities for fatty acid profile in Longissimus dorsi muscle of 216 male sheep. Genomic heritability estimates for fatty acid content ranged from 0.25 to 0.46, indicating that substantial genetic variation exists for the evaluated traits. Therefore, it is possible to alter fatty acid profiles through selection. Twenty-seven genomic regions of 10 adjacent SNPs associated with fatty acids composition were identified on chromosomes 1, 2, 3, 5, 8, 12, 14, 15, 16, 17, and 18, each explaining ≥0.30% of the additive genetic variance. Twenty-three genes supporting the understanding of genetic mechanisms of fat composition in sheep were identified in these regions, such as DGAT2, TRHDE, TPH2, ME1, C6, C7, UBE3D, PARP14, and MRPS30. Estimates of genomic heritabilities and elucidating important genomic regions can contribute to a better understanding of the genetic control of fatty acid deposition and improve the selection strategies to enhance meat quality and health attributes.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 50 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 50 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 12 24%
Researcher 7 14%
Professor 5 10%
Student > Doctoral Student 5 10%
Student > Master 3 6%
Other 5 10%
Unknown 13 26%
Readers by discipline Count As %
Agricultural and Biological Sciences 23 46%
Biochemistry, Genetics and Molecular Biology 3 6%
Veterinary Science and Veterinary Medicine 3 6%
Unspecified 1 2%
Business, Management and Accounting 1 2%
Other 3 6%
Unknown 16 32%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 July 2018.
All research outputs
#13,369,068
of 23,070,218 outputs
Outputs from BMC Genomics
#4,797
of 10,702 outputs
Outputs of similar age
#165,110
of 330,209 outputs
Outputs of similar age from BMC Genomics
#103
of 260 outputs
Altmetric has tracked 23,070,218 research outputs across all sources so far. This one is in the 41st percentile – i.e., 41% of other outputs scored the same or lower than it.
So far Altmetric has tracked 10,702 research outputs from this source. They receive a mean Attention Score of 4.7. This one has gotten more attention than average, scoring higher than 53% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 330,209 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 260 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 58% of its contemporaries.