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A rat model of hypohidrotic ectodermal dysplasia carries a missense mutation in the Edaradd gene

Overview of attention for article published in BMC Genetics, January 2011
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Mentioned by

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1 tweeter

Citations

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13 Dimensions

Readers on

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21 Mendeley
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Title
A rat model of hypohidrotic ectodermal dysplasia carries a missense mutation in the Edaradd gene
Published in
BMC Genetics, January 2011
DOI 10.1186/1471-2156-12-91
Pubmed ID
Authors

Takashi Kuramoto, Mayuko Yokoe, Ryoko Hashimoto, Hiroshi Hiai, Tadao Serikawa

Abstract

Hypohidrotic ectodermal dysplasia (HED) is a congenital disorder characterized by sparse hair, oligodontia, and inability to sweat. It is caused by mutations in any of three Eda pathway genes: ectodysplasin (Eda), Eda receptor (Edar), and Edar-associated death domain (Edaradd), which encode ligand, receptor, and intracellular adaptor molecule, respectively. The Eda signaling pathway activates NF-κB, which is central to ectodermal differentiation. Although the causative genes and the molecular pathway affecting HED have been identified, no curative treatment for HED has been established. Previously, we found a rat spontaneous mutation that caused defects in hair follicles and named it sparse-and-wavy (swh). Here, we have established the swh rat as the first rat model of HED and successfully identified the swh mutation.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 19%
Other 2 10%
Student > Bachelor 2 10%
Student > Postgraduate 2 10%
Student > Doctoral Student 2 10%
Other 5 24%
Unknown 4 19%
Readers by discipline Count As %
Medicine and Dentistry 10 48%
Agricultural and Biological Sciences 5 24%
Biochemistry, Genetics and Molecular Biology 3 14%
Unknown 3 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 October 2011.
All research outputs
#3,142,341
of 4,702,736 outputs
Outputs from BMC Genetics
#339
of 515 outputs
Outputs of similar age
#41,384
of 70,614 outputs
Outputs of similar age from BMC Genetics
#8
of 12 outputs
Altmetric has tracked 4,702,736 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 515 research outputs from this source. They receive a mean Attention Score of 3.2. This one is in the 34th percentile – i.e., 34% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 70,614 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.