Title |
An overview of HCV molecular biology, replication and immune responses
|
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Published in |
Virology Journal, April 2011
|
DOI | 10.1186/1743-422x-8-161 |
Pubmed ID | |
Authors |
Usman A Ashfaq, Tariq Javed, Sidra Rehman, Zafar Nawaz, Sheikh Riazuddin |
Abstract |
Hepatitis C virus (HCV) causes acute and chronic hepatitis which can eventually lead to permanent liver damage, hepatocellular carcinoma and death. Currently, there is no vaccine available for prevention of HCV infection due to high degree of strain variation. The current treatment of care, Pegylated interferon α in combination with ribavirin is costly, has significant side effects and fails to cure about half of all infections. In this review, we summarize molecular virology, replication and immune responses against HCV and discussed how HCV escape from adaptive and humoral immune responses. This advance knowledge will be helpful for development of vaccine against HCV and discovery of new medicines both from synthetic chemistry and natural sources. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United Kingdom | 4 | <1% |
Germany | 3 | <1% |
Netherlands | 1 | <1% |
Brazil | 1 | <1% |
Cameroon | 1 | <1% |
Egypt | 1 | <1% |
Nigeria | 1 | <1% |
China | 1 | <1% |
Spain | 1 | <1% |
Other | 1 | <1% |
Unknown | 434 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 101 | 22% |
Student > Bachelor | 75 | 17% |
Student > Ph. D. Student | 65 | 14% |
Researcher | 36 | 8% |
Student > Doctoral Student | 24 | 5% |
Other | 61 | 14% |
Unknown | 87 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 104 | 23% |
Medicine and Dentistry | 82 | 18% |
Biochemistry, Genetics and Molecular Biology | 73 | 16% |
Immunology and Microbiology | 36 | 8% |
Chemistry | 16 | 4% |
Other | 40 | 9% |
Unknown | 98 | 22% |