Title |
Focal segmental glomerulosclerosis: molecular genetics and targeted therapies
|
---|---|
Published in |
BMC Nephrology, July 2015
|
DOI | 10.1186/s12882-015-0090-9 |
Pubmed ID | |
Authors |
Ying Maggie Chen, Helen Liapis |
Abstract |
Recent advances show that human focal segmental glomerulosclerosis (FSGS) is a primary podocytopathy caused by podocyte-specific gene mutations including NPHS1, NPHS2, WT-1, LAMB2, CD2AP, TRPC6, ACTN4 and INF2. This review focuses on genes discovered in the investigation of complex FSGS pathomechanisms that may have implications for the current FSGS classification scheme. It also recounts recent recommendations for clinical management of FSGS based on translational studies and clinical trials. The advent of next-generation sequencing promises to provide nephrologists with rapid and novel approaches for the diagnosis and treatment of FSGS. A stratified and targeted approach based on the underlying molecular defects is evolving. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 2 | 20% |
Mexico | 1 | 10% |
Argentina | 1 | 10% |
Unknown | 6 | 60% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 9 | 90% |
Science communicators (journalists, bloggers, editors) | 1 | 10% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Denmark | 1 | 1% |
Germany | 1 | 1% |
Unknown | 82 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 12 | 14% |
Student > Ph. D. Student | 11 | 13% |
Student > Doctoral Student | 9 | 11% |
Student > Master | 8 | 10% |
Student > Bachelor | 8 | 10% |
Other | 20 | 24% |
Unknown | 16 | 19% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 24 | 29% |
Biochemistry, Genetics and Molecular Biology | 12 | 14% |
Agricultural and Biological Sciences | 12 | 14% |
Unspecified | 4 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 4% |
Other | 10 | 12% |
Unknown | 19 | 23% |