↓ Skip to main content

Efficacy and safety of oral branched-chain amino acid supplementation in patients undergoing interventions for hepatocellular carcinoma: a meta-analysis

Overview of attention for article published in Nutrition Journal, July 2015
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (89th percentile)

Mentioned by

1 blog
4 tweeters
2 Facebook pages


29 Dimensions

Readers on

77 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Efficacy and safety of oral branched-chain amino acid supplementation in patients undergoing interventions for hepatocellular carcinoma: a meta-analysis
Published in
Nutrition Journal, July 2015
DOI 10.1186/s12937-015-0056-6
Pubmed ID

Ling Chen, Yaqin Chen, Xiwei Wang, Hong Li, Hongmin Zhang, Jiaojiao Gong, Shasha Shen, Wenwei Yin, Huaidong Hu


Most hepatocellular carcinoma (HCC) patients have complications, including cirrhosis and malnutrition. The efficacy of dietary supplementation with oral branched-chain amino acids (BCAAs) in HCC patients undergoing interventions has not been confirmed. Relevant publications on the efficacy and safety of oral BCAA supplementation for HCC patients undergoing anti-HCC interventions through September, 2014 were searched for identification in the PubMed, Embase, Web of Science, and the Cochrane Library databases. The pooled risk ratio (RR) and standardized mean difference (SMD) were used to assess the supplementation effects. A total of 11 eligible studies (974 patients in total) were evaluated and included in our analysis. Oral BCAA supplementation helped to maintain liver reserve with higher serum albumin (SMD = 0.234, 95 % CI: 0.033-0.435, P = 0.022), and lower rates of ascites (RR = 0.545, 95 % CI: 0.316-0.938, P = 0.029) and edema (RR = 0.494, 95 % CI: 0.257-0.952, P = 0.035) than in the control group. BCAA supplementation seemed to be effective in improving mortality, especially in Child-Pugh class B patients, but the efficacy was not confirmed. Apparent effects were not found in improving HCC recurrence, total bilirubin, ALT, or AST. BCAA supplementation was relatively safe without serious adverse events. BCAA supplementation may be clinically applied in improving liver functional reserve for HCC patients and further improving the quality of life.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 77 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 77 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 13 17%
Student > Postgraduate 9 12%
Researcher 8 10%
Student > Ph. D. Student 8 10%
Student > Doctoral Student 5 6%
Other 18 23%
Unknown 16 21%
Readers by discipline Count As %
Medicine and Dentistry 22 29%
Nursing and Health Professions 10 13%
Agricultural and Biological Sciences 7 9%
Biochemistry, Genetics and Molecular Biology 4 5%
Neuroscience 3 4%
Other 14 18%
Unknown 17 22%

Attention Score in Context

This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 November 2016.
All research outputs
of 21,044,876 outputs
Outputs from Nutrition Journal
of 1,374 outputs
Outputs of similar age
of 244,796 outputs
Outputs of similar age from Nutrition Journal
of 1 outputs
Altmetric has tracked 21,044,876 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,374 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 33.1. This one has gotten more attention than average, scoring higher than 66% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 244,796 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them