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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Visualization of regional tau deposits using 3H-THK5117 in Alzheimer brain tissue
|
|---|---|
| Published in |
Acta Neuropathologica Communications, July 2015
|
| DOI | 10.1186/s40478-015-0220-4 |
| Pubmed ID | |
| Authors |
Laetitia Lemoine, Laure Saint-Aubert, Amelia Marutle, Gunnar Antoni, Jonas P Eriksson, Bernardino Ghetti, Nobuyuki Okamura, Inger Nennesmo, Per-Göran Gillberg, Agneta Nordberg |
| Abstract |
The accumulation of neurofibrillary tangles, composed of aggregated hyperphosphorylated tau protein, starts spreading early in specific regions in the course of Alzheimer's disease (AD), correlating with the progression of memory dysfunction. The non-invasive imaging of tau could therefore facilitate the early diagnosis of AD, differentiate it from other dementing disorders and allow evaluation of tau immunization therapy outcomes. In this study we characterized the in vitro binding properties of THK5117, a tentative radiotracer for positron emission tomography (PET) imaging of tau brain deposits. Saturation and competition binding studies of (3)H-THK5117 in post-mortem AD brain tissue showed the presence of multiple binding sites. THK5117 binding was significantly higher in hippocampal (p < 0.001) and temporal (p < 0.01) tissue homogenates in AD compared to controls. Autoradiography studies with (3)H-THK5117 was performed on large frozen brain sections from three AD cases who had been followed clinically and earlier undergone in vivo (18)F-FDG PET investigations. The three AD cases showed distinct differences in regional THK5117 binding that were also observed in tau immunohistopathology as well as in clinical presentation. A negative correlation between in vivo (18)F-FDG PET and in vitro (3)H-THK5117 autoradiography was observed in two of the three AD cases. This study supports that new tau PET tracers will provide further understanding on the role of tau pathology in the diversity of the clinical presentation in AD. |
X Demographics
The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 20% |
| Venezuela, Bolivarian Republic of | 1 | 20% |
| United Kingdom | 1 | 20% |
| Unknown | 2 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 4 | 80% |
| Scientists | 1 | 20% |
Mendeley readers
The data shown below were compiled from readership statistics for 74 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Unknown | 73 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 22% |
| Researcher | 16 | 22% |
| Student > Master | 7 | 9% |
| Professor | 6 | 8% |
| Other | 5 | 7% |
| Other | 15 | 20% |
| Unknown | 9 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 15 | 20% |
| Medicine and Dentistry | 12 | 16% |
| Agricultural and Biological Sciences | 7 | 9% |
| Chemistry | 5 | 7% |
| Biochemistry, Genetics and Molecular Biology | 3 | 4% |
| Other | 16 | 22% |
| Unknown | 16 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 January 2016.
All research outputs
#2,463,105
of 22,816,807 outputs
Outputs from Acta Neuropathologica Communications
#429
of 1,373 outputs
Outputs of similar age
#33,152
of 263,464 outputs
Outputs of similar age from Acta Neuropathologica Communications
#3
of 22 outputs
Altmetric has tracked 22,816,807 research outputs across all sources so far. Compared to these this one has done well and is in the 88th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,373 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.9. This one has gotten more attention than average, scoring higher than 68% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 263,464 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 86% of its contemporaries.