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Arthralgia among women taking aromatase inhibitors: is there a shared inflammatory mechanism with co-morbid fatigue and insomnia?

Overview of attention for article published in Breast Cancer Research, June 2015
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (69th percentile)
  • Above-average Attention Score compared to outputs of the same age and source (52nd percentile)

Mentioned by

twitter
5 tweeters

Citations

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23 Dimensions

Readers on

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73 Mendeley
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Title
Arthralgia among women taking aromatase inhibitors: is there a shared inflammatory mechanism with co-morbid fatigue and insomnia?
Published in
Breast Cancer Research, June 2015
DOI 10.1186/s13058-015-0599-7
Pubmed ID
Authors

Joshua Bauml, Lu Chen, Jinbo Chen, Jean Boyer, Michael Kalos, Susan Q. Li, Angela DeMichele, Jun J. Mao

Abstract

Arthralgia is a common toxicity among women taking aromatase inhibitors (AIs) and can lead to premature discontinuation of therapy. We evaluated the association between arthralgia, co-morbid fatigue/insomnia and inflammatory biomarkers among women taking AIs. Women taking AIs for early stage breast cancer completed a modified version of the Brief Pain Inventory, the Brief Fatigue Inventory, the Insomnia Severity Index, and provided blood samples for simultaneous assessment of 34 inflammatory biomarkers using a Luminex kit. Two-sided t-tests were used to compare inflammatory biomarker concentrations for patients with or without moderate to severe arthralgia. Multivariate linear regression analyses were performed to evaluate the relationship between comorbid arthralgia, fatigue and insomnia with identified biomarker concentrations. Among 203 participants, severity of arthralgia, fatigue and insomnia significantly correlated with each other (p < 0.001 for all comparisons). After controlling for race, chemotherapy history, NSAID use, age and BMI, the co-existence of arthralgia, fatigue and insomnia was associated with elevated CRP (β 93.1, 95 % Confidence Interval (CI) [25.1, 161.1], p = 0.008), Eotaxin (β 79.9, 95 % CI [32.5, 127.2], p = 0.001), MCP-1 (β 151.2, 95 % CI [32.7, 269.8], p = 0.013), and VDBP (β 19422, 95 % CI [5500.5, 33344], p = 0.006). Among women taking AIs, the co-existence of arthralgia, fatigue and insomnia was associated with increased levels of inflammatory biomarkers (elevated CRP, Eotaxin, MCP-1 and VDBP). These findings suggest a possible shared inflammatory mechanism underlying these common symptoms.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 73 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 73 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 12 16%
Student > Ph. D. Student 10 14%
Student > Master 9 12%
Researcher 8 11%
Other 5 7%
Other 15 21%
Unknown 14 19%
Readers by discipline Count As %
Medicine and Dentistry 22 30%
Nursing and Health Professions 10 14%
Neuroscience 6 8%
Pharmacology, Toxicology and Pharmaceutical Science 4 5%
Psychology 4 5%
Other 8 11%
Unknown 19 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 August 2016.
All research outputs
#3,710,750
of 12,787,140 outputs
Outputs from Breast Cancer Research
#556
of 1,448 outputs
Outputs of similar age
#69,394
of 231,249 outputs
Outputs of similar age from Breast Cancer Research
#9
of 19 outputs
Altmetric has tracked 12,787,140 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 1,448 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.0. This one has gotten more attention than average, scoring higher than 60% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 231,249 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 69% of its contemporaries.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 52% of its contemporaries.